Statistical analysis of adaptive response in sister chromatid exchanges in human lymphocytes after treatment with very... to control variability

ABSTRACT

Previous studies have been interpreted as suggesting that low concentrations of N-methyl-N'-nitrosoguanidine (MNNG) have an adaptive effect in the cultured lymphocytes of responsive donors (that is, the cells are protected against the mutagenic effects of a subsequent challenge with a higher concentration of MNNG). The objectives of the present study were to investigate, under stringent experimental conditions, whether a protective effect...(AU)