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The role of GLUT2 in dietary sugar handling
Leturque, A; Brot-Laroche, E; Gall, M. Le; Stolarczyk, E; Tobin, V.
Afiliação
  • Leturque, A; Institut Biomédical des Cordeliers. Paris. France
  • Brot-Laroche, E; Institut Biomédical des Cordeliers. Paris. France
  • Gall, M. Le; Institut Biomédical des Cordeliers. Paris. France
  • Stolarczyk, E; Institut Biomédical des Cordeliers. Paris. France
  • Tobin, V; Institut Biomédical des Cordeliers. Paris. France
J. physiol. biochem ; 61(4): 529-538, oct.-dic. 2005. ilus
Artigo em En | IBECS | ID: ibc-045370
Biblioteca responsável: ES1.1
Localização: ES1.1 - BNCS
RESUMEN
GLUT2 is a facilitative glucose transporter located in the plasma membrane of theliver, pancreatic, intestinal, kidney cells as well as in the portal and the hypothalamusareas. Due to its low affinity and high capacity, GLUT2 transports dietary sugars,glucose, fructose and galactose in a large range of physiological concentrations, displayinglarge bidirectional fluxes in and out the cells. This review focuses on the rolesof GLUT2. The first identified function of GLUT2 is its capacity to fuel metabolismand to provide metabolites stimulating the transcription of glucose sensitive genes.Recently, two other functions of GLUT2 are uncovered. First, the insertion ofGLUT2 into the apical membrane of enterocytes induces the acute regulation ofintestinal sugar absorption after a meal. Second, the GLUT2 protein itself initiates aprotein signalling pathway triggering a glucose signal from the plasma membrane tothe transcription machinery
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Proteínas de Transporte / Sacarose na Dieta Limite: Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2005 Tipo de documento: Artigo Instituição/País de afiliação: Institut Biomédical des Cordeliers/France
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Proteínas de Transporte / Sacarose na Dieta Limite: Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2005 Tipo de documento: Artigo Instituição/País de afiliação: Institut Biomédical des Cordeliers/France
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