Survival of Mexican patients with paediatric-onset systemic lupus erythematosus and abnormal electroencephalogram
Allergol. immunopatol
; 41(2): 108-113, mar.-abr. 2013. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-111621
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
Over the past three decades, there has been a remarkable improvement in the outcome of children diagnosed with systemic lupus erythematosus (SLE). In general, paediatric-onset SLE has been associated with higher mortality rates and more disease damage than adults with SLE. The objective was to determinate the impact of clinical, laboratory, and electroencephalographic findings on survival amongst patients with paediatric-onset SLE.Methods:
Charts of Mexican patients with paediatric-onset SLE diagnosed between 1970 and 2001 were analysed retrospectively; univariate and multivariate analyses were used for analysing associations between clinical and laboratory features and death; KaplanMeier tests were used to estimate survival curves.Results:
159 patients were included, 105 were female, with a median age of 12.7 years at diagnosis and a median duration of symptoms prior to diagnosis of 8.4 months. Univariate analysis showed that haematuria, leukocyturia, proteinuria, presence of urine cast, <60% glomerular filtration rate, haemolytic anaemia, and abnormal electroencephalogram, were all poor prognostic factors (p<0.05). Multivariate analysis showed that the presence of proteinuria and abnormal electroencephalograms (p<0.05) were independent factors associated with death. The overall survival rate was 82.9% at five years and 77.4% at ten years upon follow-up. Infection and high disease activity were the most common causes of death.Conclusions:
Survival of paediatric-onset SLE patients was lower compared to that reported for patients in wealthier countries. Amongst the patients who died, the presence of proteinuria and abnormal electroencephalograms were found to be determinant for survival. Infection and activity were the most common causes of death(AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Prognóstico
/
Eletroencefalografia
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
México
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran/Mexico
/
Instituto Nacional de Pediatría/Mexico