erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis
Med. oral patol. oral cir. bucal (Internet)
; 18(2): 325-331, mar. 2013. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-112405
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objetive The aim of this study was to determine erbB expression in normal mucosa, oral dysplasia, and invasive carcinomas developed in the hamsters buccal pouch chemical carcinogenesis model. Study design:
Fifty Syrian golden hamsters were equally divided in five groups (A-E); two controls and three experimental group exposed to alcohol, DMBA, or both for 14 weeks. Number of tumors per cheek, volume, histological condition, erbB expression were determined and results were analyzed by the MannWhitney U and Dunns test.Results:
Control groups and those exposed to alcohol (A, B and C respectively) only presented clinical and histological normal mucosa; while those exposed to DMBA or DMBA plus alcohol (D and E groups) developed dysplasia and invasive carcinomas. erbB2, erbB3, and erbB4 increased their expression in alcohol-exposed mucosa, dysplasia, and invasive carcinomas. We observed a similar expression level for erbB2 in dysplasia and carcinomas; while, erbB3 and erbB4 were similar only in carcinomas.Conclusion:
The DMBA and alcohol can be considered as carcinogen and promoter for oral carcinogenesis. TheerbB expression is different according to their histological condition, suggesting differential participation of theerbB family in oral carcinogenesis induced by alcohol and DMBA (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Testes de Carcinogenicidade
/
Genes erbB
/
Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
National Autonomous University of México/México
/
Health Ministry/México
/
National Autonomous University of Mexico/México
/
National Autonomous University of México/México