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Single-Nucleotide Polymorphisms of TNFA and IL1 in Allergic Rhinitis
Nasiri, R; Akbar Amirzargar, A; Movahedi, M; Hirbod-Mobarakeh, A; Farhadi, E; Behniafard, N; Tavakkol, M; Ansaripour, B; Moradi, B; Zare, A; Rezaei, N.
Afiliação
  • Nasiri, R; Tehran University of Medical Sciences. Children's Medical Center. Tehran. Iran
  • Akbar Amirzargar, A; Tehran University of Medical Sciences. School of Medicine. Tehran. Iran
  • Movahedi, M; Tehran University of Medical Sciences. Children's Medical Center. Tehran. Iran
  • Hirbod-Mobarakeh, A; Tehran University of Medical Sciences. School of Medicine. Tehran. Iran
  • Farhadi, E; Tehran University of Medical Sciences. School of Medicine. Tehran. Iran
  • Behniafard, N; Tehran University of Medical Sciences. Children's Medical Center. Tehran. Iran
  • Tavakkol, M; Tehran University of Medical Sciences. Children's Medical Center. Tehran. Iran
  • Ansaripour, B; Tehran University of Medical Sciences. School of Medicine. Tehran. Iran
  • Moradi, B; Tehran University of Medical Sciences. School of Medicine. Tehran. Iran
  • Zare, A; Tehran University of Medical Sciences. Asthma and Allergy Research Institute. Tehran. Iran
  • Rezaei, N; Tehran University of Medical Sciences. Children's Medical Center. Tehran. Iran
J. investig. allergol. clin. immunol ; 23(7): 455-461, nov.-dic. 2013. tab
Artigo em Inglês | IBECS | ID: ibc-117660
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Background:

Allergic rhinitis is a complex polygenic disorder of the upper respiratory tract. Given that proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL) 1 seem to play a role in the development of allergic rhinitis, we evaluated the associations between various single-nucleotide polymorphisms (SNPs) of the TNF and IL1 genes in a case-control study.

Methods:

The study population comprised 98 patients with allergic rhinitis. Genotyping was performed using polymerase chain reaction with sequence-specific primers for 2 TNFA promoter variants (rs1800629 and rs361525), 1 variant in the promoter region of IL1A (rs1800587), 2 SNPs in the IL1B gene (rs16944 and rs1143634), 1 variant in the IL1 receptor (rs2234650), and 1 in IL1RA (rs315952).

Results:

Patients who were homozygous for the T allele of rs16944 in IL1B had an 8.1-fold greater risk of allergic rhinitis than those with the C allele. In TNFA, a significant relationship was also detected between rs1800629 and rs361525 and allergic rhinitis. Except for rs1800587 in IL1A and rs315952 in IL1RA, significant differences were found between the patient and control groups for all other SNPs.

Conclusions:

We found that allelic variants in the TNFA and IL1 genes were not only associated with the risk of developing allergic rhinitis, but also affected disease course and severity (AU)
RESUMEN
Antecedentes La rinitis alérgica es una alteración poligénica compleja de las vías respiratorias. El TNF y la familia de la IL-1, como citoquinas proinflamatorias, parecen jugar un papel en el desarrollo de la rinitis alérgica. En este estudio de casos y controles, se evalúan las posibles asociaciones de diferentes polimorfismos de nucleótidos simples (SNPs) de los genes que regulan TNF- α e IL1.

Métodos:

Se estudiaron 19 pacientes con rinitis alérgica, los cuales fueron genotipados mediante PCR para primeras especie-específicos, para dos variantes del promotor del TNF- α (rs1800629 y rs361525), uno en el receptor de IL1 (rs2234650), dos SNPs en el gen de IL1ß (rs16944 y rs1143634), uno en el receptor de IL1 receptor (rs2234650) y IL1RA (rs315952).

Resultados:

En cuanto a los resultados obtenidos, los pacientes homicigotos para el alelo T de rs16944 en IL1ß mostraron un riesgo 8.1 veces mayor de tener rinitis alérgica que los que presentaban el alelo C. Con respecto al TNF- α, se observó una relación significativa entre los dos SNPs rs1800629 y rs361525 con la presentación de una rinitis alérgica. Excepto rs1800587, en IL1 α, y rs315952 en IL1RA, encuentran una diferencia significativa entre el grupo control y el de pacientes para el resto de los SNPs. Algunos SNPs se asociaron con el curso y con la gravedad de la enfermedad.

Conclusiones:

En conclusión, encontramos variantes genéticas de TNF-α y IL1 que se asocian con el riesgo de desarrollar una rinitis alérgica, y que también afectan al curso y gravedad de la enfermedad (AU)
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Rinite Alérgica Perene / Polimorfismo de Nucleotídeo Único Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Inglês Revista: J. investig. allergol. clin. immunol Ano de publicação: 2013 Tipo de documento: Artigo Instituição/País de afiliação: Tehran University of Medical Sciences/Iran
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Rinite Alérgica Perene / Polimorfismo de Nucleotídeo Único Tipo de estudo: Estudo observacional / Fatores de risco Limite: Humanos Idioma: Inglês Revista: J. investig. allergol. clin. immunol Ano de publicação: 2013 Tipo de documento: Artigo Instituição/País de afiliação: Tehran University of Medical Sciences/Iran
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