Burkitts lymphoma of the jaws in the Amazon region of Brazil
Med. oral patol. oral cir. bucal (Internet)
; 19(1): e32-e38, ene. 2014. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-118250
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
OBJECTIVES:
To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil. StudyDESIGN:
Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV).RESULTS:
Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis.CONCLUSIONS:
Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinico-pathologic features to those described in endemic areas of Africa, including EBV positivityRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Mandibulares
/
Linfoma de Burkitt
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Federal University of Pará/s. p
/
State University of Campinas/Brazil
/
University of São Paulo/Brazil