Expression of hormonal receptors in osteosarcomas of the jaw bones: Clinico-pathological analysis of 21 cases
Med. oral patol. oral cir. bucal (Internet)
; 19(1): e44-e48, ene. 2014.
Artigo
em Inglês
| IBECS
| ID: ibc-118252
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Sexual hormones have an important role in many hormone-dependant tumors like breast and prostate carcinomas, and also a relationship has been found with bone metabolism and bone tumors. Some studies have demonstrated that the expression of hormonal receptors (HR) in osteosarcomas (OS) of long bones is associd with gender, histological grade, histological type, and possibly may be connection with pathogenesis and evolution. However, to our knowledge there are no studies of HR in osteosarcomas of craniofacial bones (OS-CF).OBJECTIVES:
To assess the expression of hormonal receptors in OS-CF. MATERIAL ANDMETHODS:
Twenty one cases of OS-CF were included in this study. Clinical outcome was obtained from clinical charts. Histological sections were reviewed, and immunohistochemistry studies for estrogen, progesterone and androgen receptors were performed.RESULTS:
A striking female predominance was found (21), with a median age of 35 years. The predominant type of OS was osteoblastic (52.4%), and histological grade was high in 86%. Follow-up was obtained in 13 cases and ranged from 6 to 118 months (median 29 months). There were 8 patients (61.5%) dead or alive with progressive disease in the last follow up. Negative expression of HR was found in 19/21 cases; one showed weak nuclear expression for estrogen receptor, and another for androgen receptor. Progesterone receptor was negative in all cases.CONCLUSIONS:
OS-CF mostly affected females, most of them were of the osteoblastic type and of high grade. Hormonal expression was practically negative in osteosarcoma of craniofacial bonesRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias Maxilomandibulares
/
Receptores Androgênicos
/
Receptores de Esteroides
/
Osteossarcoma
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Nacional de Cancerología/México
/
Universidad Autónoma Metropolitana Xochimilco/México