Your browser doesn't support javascript.
loading
The relationship between serum vitamin A and breast cancer staging before and after radiotherapy / La relación entre la concentración de vitamina A y estadificación del cáncer de mama antes y después de la radioterapia
Matos, Andréa; Nogueira, Carla; Franca, Carlos; Ramalho, Andréa; Vieira, Sérgio Lannes; Penna, Antônio; Carvalho, Antônio.
Afiliação
  • Matos, Andréa; Federal University of Rio de Janeiro. Micronutrients Research Center (NPqM). Social Applied Nutrition Department. Brazil
  • Nogueira, Carla; Federal University of Rio de Janeiro. Micronutrients Research Center (NPqM). Social Applied Nutrition Department. Brazil
  • Franca, Carlos; Federal University of Rio de Janeiro. Micronutrients Research Center (NPqM). Social Applied Nutrition Department. Brazil
  • Ramalho, Andréa; Federal University of Rio de Janeiro. Micronutrients Research Center (NPqM). Social Applied Nutrition Department. Brazil
  • Vieira, Sérgio Lannes; Brazilian Institute of Oncology (IBO). Ingá Radiotherapy Clinic (CRI). Department of Radiation Oncology. Brazil
  • Penna, Antônio; Brazilian Institute of Oncology (IBO). Ingá Radiotherapy Clinic (CRI). Department of Radiation Oncology. Brazil
  • Carvalho, Antônio; Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Department of Radiology. Brazil
Nutr. hosp ; 29(1): 136-139, ene. 2014. tab
Artigo em Inglês | IBECS | ID: ibc-120565
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Introduction:

Several adverse effects of radiotherapy have been associated with the process of increased oxidative stress in the organism. In this context, vitamin A noteworthy for its important role in combating oxidative stress, in addition to its chemoprotective effect.

Objective:

To assess the serum levels of vitamin A (retinol and β-carotene) and their relationship to breast cancer staging in patients before and after radiotherapy.

Methods:

This is a prospective study of women with breast cancer who were evaluated from October 2011 to September 2012 before (T0) and after radiotherapy (T1-7 days). Serum retinol and β-carotene levels were analyzed using High Performance Liquid Chromatography. The assignment of breast cancer stages was based on the classification of malignant tumors that has been proposed by the International Union Against Cancer.

Results:

230 patients (mean age 63.6 years, SD ± 9.38) were evaluated. There was a significant reduction in the serum retinol (45.1 ± 18.2 μg/dL at T0 to 27.1 ± 11.7 μg/dL at T1, p < 0.001) and β-carotene (209.0 ± 153.6 μg/L at T0 to 47.7 ± 25.5 μg/L at T1, p < 0.001). There was also a significant difference in serum retinol (p < 0.001) and β-carotene (p = 0.003) levels based on the disease stage.

Conclusions:

It is recommended the early establishment of adequation serum concentrations of retinol and beta-carotene, offering nutritional assistance for those patients with deficiencies, in order to minimize the harmful effects of radiation (AU)
RESUMEN

Introducción:

Varios efectos adversos de la radioterapia se han asociado con el proceso de aumento de estrés oxidativo en el organismo. En este contexto, la vitamina A se destaca por su papel importante en la lucha contra el estrés oxidativo, además de su efecto quimioprotector.

Objetivo:

Evaluar los niveles séricos de la vitamina A (retinol y β-caroteno) y su relación con la estadificación del cáncer de mama en pacientes antes y después de la radioterapia.

Métodos:

Se realizó un estudio prospectivo de mujeres con cáncer de mama que fueron evaluadas desde octubre 2011 a septiembre 2012 antes (T0) y después de la radioterapia (T1-7 días). Retinol sérico y los niveles de β-caroteno se analizaron mediante cromatografía líquida de alto rendimiento. La asignación de las etapas del cáncer de mama se basa en la clasificación de los tumores malignos que se han propuesto por la Unión Internacional contra el Cáncer.

Resultados:

230 pacientes (edad media de 63,6 años, SD + 9,38) fueron evaluados. Hubo una reducción significativa en el retinol sérico (45.1 ± 18.2 μg/dL en T0 a 27.1 ± 11.7 μg/dL en T1, p < 0.001) y β-caroteno (209.0 ± 153.6 μg/L en T0 a 47.7 ± 25.5 μg/L en T1, p < 0.001). También hubo una diferencia significativa en el retinol sérico (p < 0,001) y los niveles de β-caroteno (p = 0,003) sobre la base de la etapa de la enfermedad.

Conclusiones:

Se recomienda el pronto establecimiento de la adecuación de las concentraciones séricas de retinol y beta-caroteno, ofreciendo asistencia nutricional para los pacientes con deficiencias, con el fin de minimizar los efectos nocivos de la radiación (AU)
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Vitamina A / Neoplasias da Mama / Beta Caroteno Tipo de estudo: Estudo de avaliação / Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Nutr. hosp Ano de publicação: 2014 Tipo de documento: Artigo Instituição/País de afiliação: Brazilian Institute of Oncology (IBO)/Brazil / Federal University of Rio de Janeiro/Brazil

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Vitamina A / Neoplasias da Mama / Beta Caroteno Tipo de estudo: Estudo de avaliação / Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Nutr. hosp Ano de publicação: 2014 Tipo de documento: Artigo Instituição/País de afiliação: Brazilian Institute of Oncology (IBO)/Brazil / Federal University of Rio de Janeiro/Brazil
...