Aqueous seed extract of Syzygium cuminiinhibits the dipeptidyl peptidase IV and adenosine deaminase activities, but it does not change the CD26 expression in lymphocytes in vitro
J. physiol. biochem
; 69(1): 119-124, mar. 2013.
Artigo
em Inglês
| IBECS
| ID: ibc-121993
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Syzygium cumini (Sc) have been intensively studied in the last years due its beneficial effects including anti-diabetic and anti-inflammatory potential. Thus, the aim of this study was to evaluate the effect of aqueous seed extract of Sc (ASc) in the activity of enzymes involved in lymphocyte functions. To perform this study, we isolated lymphocytes from healthy donors. Lymphocytes were exposed to 10, 30, and 100 mg/mL of ASc during 4 and 6 h and adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV), and acetylcholinesterase (AChE) activities as well as CD26 expression and cellular viability were evaluated. ASc inhibited the ADA and DPP-IV activities without alteration in the CD26 expression (DPP-IV protein). No alterations were observed in the AChE activity or in the cell viability. These results indicate that the inhibition of the DPP-IV and ADA activities was dependent on the time of exposition to ASc. We suggest that ASc exhibits immunomodulatory properties probably via the pathway of DPP-IVADA complex, contributing to the understanding of these proceedings in the purinergic signaling (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Sementes
/
Extratos Vegetais
/
Linfócitos
/
Dipeptidil Peptidases e Tripeptidil Peptidases
/
Eugenia
Limite:
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Federal University of Santa Maria (UFSM)/Brazil
/
IPA/Brazil
/
UFSM/Brazil