Effects of curcumin and Ginkgo biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease
J. physiol. biochem
; 68(4): 529-539, dic. 2012.
Artigo
em Inglês
| IBECS
| ID: ibc-122301
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Treatment of inflammatory bowel disease (IBD) by synthetic active ingredients leads to many side effects. The objective of this study was to manage IBD using natural products as curcumin andGinkgo biloba. Rats were divided into four groups (control, IBD, curcumin treated, and ginkgo treated). Inflammation was assessed by determination of myeloperoxidase, matrix metalloproteinases, metalloproteinase-1 inhibitor, nitric oxide, hydroxyproline, tumor necrosis factor-alpha, ceruloplasmin, and histopathological scoring. IBD induction significantly increased all measured parameters. Treated groups had significantly lower levels when compared with the IBD group. In conclusion, curcumin and ginkgo were effective in prevention and treatment of IBD (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Doenças Inflamatórias Intestinais
/
Expressão Gênica
/
Ginkgo biloba
/
Metaloproteinases da Matriz
/
Curcumina
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
Cairo University/Egypt