Your browser doesn't support javascript.
loading
In vitro study of the antioxidative properties of the glucose derivatives against oxidation of plasma components
Kolodziejczyk, Joanna; Saluk-Juszczak, Joanna; Wachowicz, Barbara.
Afiliação
  • Kolodziejczyk, Joanna; University of Lodz. Institute of Biochemistry. Department of General Biochemistry. Lodz. Poland
  • Saluk-Juszczak, Joanna; University of Lodz. Institute of Biochemistry. Department of General Biochemistry. Lodz. Poland
  • Wachowicz, Barbara; University of Lodz. Institute of Biochemistry. Department of General Biochemistry. Lodz. Poland
J. physiol. biochem ; 67(2): 175-183, jun. 2011.
Artigo em Inglês | IBECS | ID: ibc-122617
Biblioteca responsável: ES1.1
Localização: BNCS
RESUMEN
No disponible
ABSTRACT
Oxidative stress has been implicated in the pathogenesis of variety of diseases. Since the endogenous antioxidant defense may be not adequate to counteract the enhanced generation of oxidants, a growing interest in research for exogenous nutrients has been observed. The present study was designed to assess in vitro the antioxidative properties of the glucose derivatives calciumD-glucarate, D-gluconic acid lactone, and sodium D-gluconate (0.5–3 mM) in the protection of plasma proteins and lipids, against the damage caused by 0.1 mM peroxynitrite (ONOO−). Exposure of plasma to ONOO− resulted in carbonyl groups increase, 3-nitrotyrosine (3-NT) formation, reduction in thiol groups, and enhanced lipid peroxidation. D-Gluconic acid lactone and sodium D-gluconate effectively decreased 3-NT formation; the antinitrative action of calcium D-glucarate was less effective. In plasma samples incubated with ONOO− and tested compounds, the level of carbonyl groups was decreased in comparison to plasma samples treated only with ONOO−. The level of protein −SH groups and glutathione was significantly higher in the presence of glucose derivatives than in plasma samples treated with ONOO− only. All the tested compounds had the inhibitory effect on the peroxynitrite-induced plasma lipids peroxidation. The results obtained from our work indicate that calcium D-glucarate, D-gluconic acid lactone, and sodium D-gluconate may partly protect plasma proteins and lipids against peroxynitrite-induced damages (AU)
Assuntos
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Gluconato de Cálcio / Gluconato de Antimônio e Sódio / Estresse Oxidativo / Lactonas / Antioxidantes Limite: Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2011 Tipo de documento: Artigo Instituição/País de afiliação: University of Lodz/Poland
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Gluconato de Cálcio / Gluconato de Antimônio e Sódio / Estresse Oxidativo / Lactonas / Antioxidantes Limite: Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2011 Tipo de documento: Artigo Instituição/País de afiliação: University of Lodz/Poland
...