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mTOR signalling in human cancer
Albanell, J; Dalmases, A; Rovira, A; Rojo, F.
Afiliação
  • Albanell, J; Hospital del Mar-IMAS. Barcelona. Spain
  • Dalmases, A; Hospital del Mar-IMAS. Barcelona. Spain
  • Rovira, A; Hospital del Mar-IMAS. Barcelona. Spain
  • Rojo, F; Hospital del Mar-IMAS. Barcelona. Spain
Clin. transl. oncol. (Print) ; 9(8): 484-493, ago. 2007. ilus
Artigo em Inglês | IBECS | ID: ibc-123345
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Inhibitors of mTOR, the mammalian target of rapamycin, have been extensively studied in clinical trials for cancer treatment. Results have been promising, mostly in certain lymphomas, but in solid tumours the results have been generally less encouraging. However, recent results, particularly in renal cell carcinoma, have provided renewed interest in the role of mTOR inhibitors in solid tumours. A rational, and potentially more successful, development of these agents (i.e., RAD001, temsirolimus and AP23573) likely relies in a deeper knowledge of mTOR signalling in cancer, both at the preclinical and clinical levels. These would allow a better selection of patients more likely to respond to the use of biologically active doses of the agents and the development of mechanistically based combinations with other agents. The goal of this review is to provide an update on the complex signalling of mTOR in cancer and on the biological effects of mTOR inhibitors in cancer cells (AU)
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Proteínas Quinases / Transdução de Sinais / Neoplasias Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2007 Tipo de documento: Artigo Instituição/País de afiliação: Hospital del Mar-IMAS/Spain
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Proteínas Quinases / Transdução de Sinais / Neoplasias Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2007 Tipo de documento: Artigo Instituição/País de afiliação: Hospital del Mar-IMAS/Spain
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