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Expression of E-cadherin, beta-catenin and topoisomerase IIalpha in leiomyosarcomas
Gogou, PN; Batistatou, A; Pakos, EE; Apostolikas, N; Stefanou, D; Tsekeris, PG.
Afiliação
  • Gogou, PN; University of Ioannina. Medical School. Ioannnina. Greece
  • Batistatou, A; University of Ioannina. Medical School. Ioannnina. Greece
  • Pakos, EE; s.af
  • Apostolikas, N; St Savras Anticancer-Oncologic-Hospital. Athens. Greece
  • Stefanou, D; University of Ioannina. Medical School. Ioannnina. Greece
  • Tsekeris, PG; University of Ioannina. Medical School. Ioannnina. Greece
Clin. transl. oncol. (Print) ; 11(8): 548-551, ago. 2009. ilus
Artigo em Inglês | IBECS | ID: ibc-123674
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

INTRODUCTION:

The expression of E-cadherin, beta-catenin and topoisomerase II has been associated with clinical outcome of several cancers including sarcomas. We aimed to evaluate the expression of these markers in leiomyosarcomas (LMS). MATERIALS AND

METHODS:

Paraffin blocks of 19 primary, nonmetastatic LMS were analysed immunohistochemically for the expression of the above-mentioned markers with a cutoff level for positivity of 20% of cell staining.

RESULTS:

Expression of E-cadherin was negative in all LMS. Nuclear expression of beta-catenin was also negative in all cases, while positive cytoplasmic beta-catenin expression was observed in approximately half of the patients. The majority of LMS had expression of topoisomerase IIalpha, although only in 10 patients was this expression in more than 20% of tumour cells. From the analysed factors, tumour size was statistically significantly correlated with relapse-free survival.

CONCLUSIONS:

Further evidence with larger series is required in order to determine the implication of these markers in LMS (AU)
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Caderinas / DNA Topoisomerases Tipo II / Proteínas de Ligação a DNA / Beta Catenina / Leiomiossarcoma / Antígenos de Neoplasias Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2009 Tipo de documento: Artigo Instituição/País de afiliação: St Savras Anticancer-Oncologic-Hospital/Greece / University of Ioannina/Greece
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Caderinas / DNA Topoisomerases Tipo II / Proteínas de Ligação a DNA / Beta Catenina / Leiomiossarcoma / Antígenos de Neoplasias Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2009 Tipo de documento: Artigo Instituição/País de afiliação: St Savras Anticancer-Oncologic-Hospital/Greece / University of Ioannina/Greece
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