Inhibiting PI3K as a therapeutic strategy against cancer
Clin. transl. oncol. (Print)
; 11(9): 572-579, sept. 2009. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-123679
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Class I PI3K is composed of heterodimeric lipid kinases regulating essential cellular functions including proliferation, apoptosis and metabolism. Class I PI3K isoforms are commonly amplified in different cancer types and the PI3Kalpha catalytic subunit, PIK3CA, has been found mutated in a variable proportion of tumours of different origin. Furthermore, PI3K has been shown to mediate oncogenic signalling induced by several oncogenes such as HER2 or Ras. These facts suggest that PI3K might be a good target for anticancer drug discovery. Today, the rise of PI3K inhibitors and their first in vivo results have cleared much of the path for the development of PI3K inhibitors for anticancer therapy. Here we will review the PI3K pathway and the pharmacological results of PI3K inhibition (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Fosfatidilinositol 3-Quinases
/
Inibidores Enzimáticos
/
Neoplasias
Tipo de estudo:
Estudo de avaliação
/
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
CSIC/Spain
/
Hospital Universitario Virgen del Rocío/Spain
/
Spanish National Cancer Research Centre/Spain