Biweekly vinorelbine and tegafur/uracil in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: GEICAM 2000-02 phase II study
Clin. transl. oncol. (Print)
; 13(4): 281-286, abr. 2011. tab
Artigo
em Inglês
| IBECS
| ID: ibc-124436
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
INTRODUCTION:
To assess the efficacy and safety profile of biweekly vinorelbine and tegafur/uracil (UFT) as treatment in patients with metastatic breast cancer previously treated with anthracyclines and taxanes. PATIENTS ANDMETHODS:
Patients with histologically confirmed breast cancer, measurable disease, no more than one prior chemotherapy regimen for metastatic disease, an Eastern Cooperative Oncology Group (ECOG) performance status ≤2, and adequate bone marrow, renal and liver function were eligible. Patients received vinorelbine (30 mg/m(2) on day 1) and UFT (250 mg/m(2) daily) every two weeks for 12 cycles unless progression or unacceptable toxicity was observed.RESULTS:
Thirty-seven patients were included and received 311 cycles of chemotherapy. Efficacy and toxicity analyses were carried out on an intention-to-treat basis. The overall response rate was 35% (95% CI 20-53). With a median follow-up of 18.6 months (95% CI 1.0-74.3), the median time to progression was 7.0 months (96% CI 5.2-8.9) and the median overall survival was 19.4 months (95% CI 11.1-27.8). The most common severe toxicities were neutropenia (38% of patients) and asthenia (11% of patients).CONCLUSION:
The combination of biweekly vinorelbine and UFT in patients with metastatic breast cancer pretreated with anthracyclines and taxanes is a well tolerated and effective regimen. AEMPS Trial Registration No. 00-0534 (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Uracila
/
Vimblastina
/
Neoplasias da Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
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Estudos Multicêntricos como Assunto
/
Tegafur
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Ensaios Clínicos Fase II como Assunto
/
Intervalo Livre de Doença
Tipo de estudo:
Ensaio clínico controlado
/
Estudo de avaliação
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Centro Oncológico de Galicia/Spain
/
Hospital General de Jaén/Spain
/
Hospital Germans Trias i Pujol/Spain
/
Hospital Universitario Miguel Servet/Spain
/
Hospital Universitario Virgen de la Victoria/Spain
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Hospital de Barbastro/Spain
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Hospital de la Santa Creu i Sant Pau/Spain
/
Pierre Fabre Ibérica SA/Spain