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Antiaterogenicidad in vitro de extractos del alga marina Halimeda incrassata: actividad antioxidante y estudios de migración en células de la musculatura lisa / In vitro antiatherogenicity of extracts from Halimeda incrassata seaweed: antioxidant activity and smooth muscle cell migration studies
Costa-Mugica, A; Batista-González, AE; Mondejar, D; Soto, Y; Brito, V; Vázquez, AM; Brömme, D; Zaldívar-Muñoz, C; Mancini-Filho, J; Vidal-Novoa, A.
Afiliação
  • Costa-Mugica, A; University of Havana. Faculty of Biology. Department of Biochemistry. Havana City. Cuba
  • Batista-González, AE; University of Havana. Faculty of Biology. Department of Biochemistry. Havana City. Cuba
  • Mondejar, D; University of Havana. Faculty of Biology. Department of Biochemistry. Havana City. Cuba
  • Soto, Y; Center for Molecular Immunology. Havana City. Cuba
  • Brito, V; Center for Molecular Immunology. Havana City. Cuba
  • Vázquez, AM; Center for Molecular Immunology. Havana City. Cuba
  • Brömme, D; University of British Columbia. Faculty of Dentistry. Department of Oral Biological and Medical Sciences. Columbia. Canada
  • Zaldívar-Muñoz, C; University of Havana. Faculty of Biology. Department of Biochemistry. Havana City. Cuba
  • Mancini-Filho, J; University of Sao Paulo. Faculty of Pharmaceutical Sciences. Department of Food and Experimental Nutrition. Sao Paulo. Brazil
  • Vidal-Novoa, A; University of Havana. Faculty of Biology. Department of Biochemistry. Havana City. Cuba
Ars pharm ; 54(2): 4-11[2], abr.-jun. 2013. tab, graf
Artigo em Inglês | IBECS | ID: ibc-129241
Biblioteca responsável: ES1.1
Localização: BNCS
RESUMEN

Objetivos:

El objetivo de este trabajo fue evaluar el potencial ateroprotector in vitro del alga Halimeda incrassata en la migración de células de músculo liso de ratón y la oxidación de lipoproteínas en relación con su actividad antioxidante. Material y

métodos:

La actividad antioxidante fue determinada mediante los métodos de inhibición de radicales DPPH y la Capacidad antioxidante total (ORAC). La actividad inhibitoria de la oxidación de LDL mediada por iones Cu2+ se determinó por la cuantificación de TBARS y dienos conjugados. El efecto del extracto acuoso sobre la migración de las células de músculo liso se evaluó en la línea de células de músculo liso aórtica de ratón MOVAS-1.

Resultados:

Se demostró el efecto inhibidor del extracto sobre la oxidación de LDL mediada por Cu2+. El extracto del alga causa inhibición dosis-dependiente de la formación de TBARS (IC50 = 0,8 mg/mL) y dienos conjugados. Las algas tuvieron una alta actividad antioxidante en los ensayos realizados y podría estar relacionada con el contenido de compuestos fenólicos.

Conclusiones:

Los resultados de este trabajo representan un paso más en la caracterización de la acción ateroprotectora de Halimeda incrassata y evidencian sus posibles aplicaciones como nutracéutico y/o fitofármaco (AU)
ABSTRACT

Aim:

The aim of this work was to evaluate the in vitro atheroprotective potential of the seaweed Halimeda incrassata in smooth muscle cell migration and lipoprotein oxidation in relation to its antioxidant activity. Material and

methods:

Antioxidant activity was determinate by DPPH• radical scavenging assay and ORAC method. The inhibitory effect of the aqueous extract on LDL oxidation mediated by Cu2+ ions was determinate by TBARS and conjugated diene quantification. The effect of the seaweed aqueous extract on smooth muscle cell migration was evaluated in MOVAS-1 mouse aortic smooth muscle cell.

Results:

The inhibitory effect of the aqueous extract on lipoprotein oxidation mediated by Cu2+ was demonstrated. Seaweed extract caused dose-dependent inhibition of TBARS (IC50 = 0.8 mg/mL) and conjugated dienes formation. The seaweed had a high antioxidant activity in the assays performed. The activity could be related to the phenolic content of Halimeda incrassata.

Conclusions:

In summary, the results of this study represent a further step in the characterization of the atheroprotective action of Halimeda incrassata and indicate the seaweed could be used for a nutraceutical and/or phytoterapeutic application (AU)
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Alga Marinha / Aterosclerose / Fitoterapia / Antioxidantes Limite: Humanos Idioma: Inglês Revista: Ars pharm Ano de publicação: 2013 Tipo de documento: Artigo Instituição/País de afiliação: Center for Molecular Immunology/Cuba / University of British Columbia/Canada / University of Havana/Cuba / University of Sao Paulo/Brazil
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Alga Marinha / Aterosclerose / Fitoterapia / Antioxidantes Limite: Humanos Idioma: Inglês Revista: Ars pharm Ano de publicação: 2013 Tipo de documento: Artigo Instituição/País de afiliação: Center for Molecular Immunology/Cuba / University of British Columbia/Canada / University of Havana/Cuba / University of Sao Paulo/Brazil
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