La urea en el manejo del síndrome de secreción inadecuada de la ADH: una revisión sistemática de la literatura / Urea for management of the syndrome of inappropriate secretion of ADH: A systematic review

RESUMEN

Recientemente se ha propuesto el uso de la urea como tratamiento complementario en el síndrome de secreción inadecuada de la ADH (SIADH). El objetivo del estudio es realizar una revisión de los niveles de evidencia de la urea en el tratamiento de la hiponatremia asociado al SIADH. Se realizó una revisión sistemática de la evidencia a partir de estudios experimentales de acuerdo con la escala propuesta por SIGN. No se encontraron ensayos clínicos. Los 6 estudios analizados presentan carencias metodológicas importantes y están muy sujetos a sesgos. En conclusión, no existe evidencia que sustente el uso de la urea en la hiponatremia asociada al SIADH. Urea has been recently proposed for the management of hyponatremia linked to the syndrome of inappropriate secretion of ADH (SIADH). The objective of the study was to review the levels of evidence for treatment of hyponatremia associated with SIADH with urea. We performed a systematic review of experimental trials and grading according to SIGN. No clinical trials were found. The 6 studies analysed had methodological limitations and were prone to biases. In conclusion, there is no evidence to support the efficacy of urea for the treatment of hyponatremia following SIADH

ABSTRACT

Urea has been recently proposed for the management of hyponatremia linked to the syndrome of inappropriate secretion of ADH (SIADH). The objective of the study was to review the levels of evidence for treatment of hyponatremia associated with SIADH with urea. We performed a systematic review of experimental trials and grading according to SIGN. No clinical trials were found. The 6 studies analysed had methodological limitations and were prone to biases. In conclusion, there is no evidence to support the efficacy of urea for the treatment of hyponatremia following SIADH. Urea has been recently proposed for the management of hyponatremia linked to the syndrome of inappropriate secretion of ADH (SIADH). The objective of the study was to review the levels of evidence for treatment of hyponatremia associated with SIADH with urea. We performed a systematic review of experimental trials and grading according to SIGN. No clinical trials were found. The 6 studies analysed had methodological limitations and were prone to biases. In conclusion, there is no evidence to support the efficacy of urea for the treatment of hyponatremia following SIADH