Immunophenotype in orofacial granulomatosis with and without Crohns disease
Med. oral patol. oral cir. bucal (Internet)
; 19(6): e584-e591, nov. 2014. tab
Artigo
em Inglês
| IBECS
| ID: ibc-130353
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
OBJECTIVES:
The aim of this investigation was to characterise and compare the inflammatory infiltrates in patients with orofacial granulomatosis solely (OFG-S) and OFG with coexisting Crohn's disease (OFG+CD). StudyDESIGN:
Biopsy specimens with granulomas were obtained from patients with OFG-S (n=11) and OFG+CD (n=11) and immunostained with antibodies against CD1a, CD3, CD4, CD8, CD11c, CD20, CD68 and mast cell tryptase, followed by quantitative analysis.RESULTS:
Analyses of the connective tissue revealed a significantly higher number of CD3-expressing T cells and CD11c-expressing dendritic cells in the connective tissue of patients with OFG-S compared to patients with OFG+CD. Mast cells displayed a high level of activation, although no significant difference was detected when comparing the two groups.CONCLUSIONS:
The results show a different composition of the inflammatory infiltrate in patients with OFG-S compared to patients with OFG+CD. The present observations support that partlydivergent immune mechanisms are involved in these two different subcategories of OFG
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Doença de Crohn
/
Imunofenotipagem
/
Granulomatose Orofacial
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2014
Tipo de documento:
Artigo
Instituição/País de afiliação:
Institute of Biomedicine/s,p
/
Institute of Clinical Sciences/s,p
/
Institute of Odontology/s,p
/
University of Gothenburg/Sweden