Nitric oxide regulates multiple functions and fate of adult progenitor and stem cells
J. physiol. biochem
; 71(1): 141-153, mar. 2015.
Artigo
em Inglês
| IBECS
| ID: ibc-133911
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Nitric oxide is an endogenous gas which exerts autocrine/paracrine actions by different signaling pathways and/or direct interactions with intracellular compounds and structures. Several processes are regulated by nitric oxide in stem cells including self-renewal, viability, migration, proliferation, and differentiation. The modulation of cell functions depends on its concentrations because opposite effects can be observed when low and high levels of nitric oxide are compared. Here, the responses to nitric oxide of adult stem/progenitor cells which are often used in regenerative medicine, including mesenchymal stem cells, hematopoietic stem cells, neural stem cells, endothelial progenitor cells, satellite cells, and fibro-adipogenic precursor cells, are reviewed. Therapeutic strategies which employ drugs releasing nitric oxide or modulating nitric oxide intracellular pathways are suggested to perform new ex vivo preconditioning or in vivo treatments suitable for stem/progenitor cell therapy and tissue engineering applications
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Comunicação Autócrina
/
Comunicação Parácrina
/
Células-Tronco Adultas
/
Óxido Nítrico
Limite:
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Bologna/Italy