The potential usefulness of human leukocyte antigen typing for celiac disease screening: a systematic review and meta-analysis
Rev. esp. enferm. dig
; 107(7): 423-429, jul. 2015.
Artigo
em Inglês
| IBECS
| ID: ibc-137619
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND AND AIM:
The presence of specific human leukocyte antigen-DQ2 and DQ8 seems to be necessary for celiac disease development, but the real contribution of its typing for screening is still uncertain. We aim to conduct a systematic review and meta-analysis of the diagnostic performance of human leukocyte antigen typing tests for celiac disease screening.METHODS:
Systematic review of published studies assessing accuracy of human leukocyte antigen DQ2 and DQ8 typing for the detection of celiac disease were selected. MEDLINE and EMBASE were searched from 1st January 2004 until 31st December 2013. Two independent researchers carried out selection and classification of studies, data extraction and analysis. Meta-analysis combining sensitivities, specificities and likelihood ratios of HLA-DQ2 and DQ8 for the diagnosis of celiac disease were carried out.RESULTS:
6 studies including 1303 individuals were finally evaluated. Pooled sensitivity was 98% (95% confidence interval 97-99). Overall specificity was 45% (95% confidence interval 41-48). Regarding specificity, studies were heterogeneous and a subgroup analysis was done according to the type of population included. Overall negative likelihood ratio was 0.05 (0.03-0.09).CONCLUSIONS:
Due to its great sensitivity and low negative likelihood ratio, human leukocyte antigen-DQ2/DQ8 typing would be an appropriate test for ruling out celiac disease in the general population suffering related symptoms, and even more in at risk populationRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Objetivo 10: Doenças transmissíveis
Base de dados:
IBECS
Assunto principal:
Doença Celíaca
/
Antígenos HLA
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
/
Revisão sistemática
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital General Universitario Gregorio Marañón/Spain
/
Hospital Universitario de La Princesa/Spain