Lung metastases in oligometastatic patients: outcome with stereotactic body radiation therapy (SBRT)
Clin. transl. oncol. (Print)
; 17(8): 668-672, ago. 2015. tab
Artigo
em Inglês
| IBECS
| ID: ibc-138182
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Purpose. To assess the clinical results in terms of local control, toxicity, failure pattern and toxicity of SBRT in oligometastatic patients with inoperable lung metastases. Methods. Forty-four patients were treated (53 metastases). Dose regimen 5 × 12 Gy (66 %), 8 × 7.5 Gy (20.8 %) and 10 × 5 Gy (13.2 %). Response was assessed using PET/CT at 6 months after SBRT. Results. Local control at 1 and 2 years was 86.7 %. Seventy-five percent of local failures had received a BED <105 Gy. After a median follow-up of 13.3 months, 25 % experienced distant progression. Overall survival at 1 and 2 years was 86.7 and 60.4 %, and cancer-specific survival was 95.3 and 75.2 %, respectively. Grade 2 toxicity was 6.8 %. There was no grade 34 toxicity. Conclusion. SBRT is effective and safe. The main failure pattern is distant progression. The selection of patients with a high probability of remaining oligometastatic is crucial for the efficiency of SBRT, both clinically and in terms of resources (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Outras Doenças Respiratórias
/
Neoplasias do Pulmão, Traqueia e Brônquios
Base de dados:
IBECS
Assunto principal:
Radioterapia
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Testes Imunológicos de Citotoxicidade
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Radiocirurgia
/
Morte Celular
/
Receptores do Fator de Necrose Tumoral
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Neoplasias Pulmonares
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Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Gustave Roussy Cancer Campus/France
/
Reina Sofia University Hospital/Spain
/
Reina Sofía University Hospital/Spain