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Effects of zoledronate on the radiation-induced collagen breakdown: a prospective randomized clinical trial
Gierloff, M; Reutemann, M; Gülses, A; Niehoff, P; Wiltfang, J; Açil, Y.
Afiliação
  • Gierloff, M; University Hospital Schleswig-Holstein. Department of Oral and Maxillofacial Surgery. Kiel. Germany
  • Reutemann, M; University Hospital Schleswig-Holstein. Department of Oral and Maxillofacial Surgery. Kiel. Germany
  • Gülses, A; Mevki Military Hospital. Center for Dentistry and Oral Health. Ankara. Turkey
  • Niehoff, P; University Hospital Köln-Merheim. Department for Radiotherapy (Radiooncology). Cologne. Germany
  • Wiltfang, J; University Hospital Schleswig-Holstein. Department of Oral and Maxillofacial Surgery. Kiel. Germany
  • Açil, Y; University Hospital Schleswig-Holstein. Department of Oral and Maxillofacial Surgery. Kiel. Germany
Clin. transl. oncol. (Print) ; 17(6): 454-461, jun. 2015. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-138714
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Background:

A negative side effect of therapeutic irradiation is the radiation-induced bone loss which can lead, in long term, to pathological fractures. Until today, the detailed mechanism is unknown. If osteoclasts would mainly contribute to the pathological bone loss, bisphosphonates could potentially counteract the osteolytic process and possibly help to prevent long-term complications. The aim of this study was to evaluate the effect of zoledronic acid on the early radiation-induced degradation of bone collagen fibrils by monitoring the urinary excretion of hydroxylysylpyridinoline and lysylpyridinoline under radiotherapy. Patients and

methods:

A total of 40 patients with skeletal metastases were assigned for a local radiotherapy and bisphosphonate treatment. The patients were prospectively randomized into two treatment groups group A (n = 20) received the first zoledronate administration after and group B (n = 20) prior to the radiotherapy. Urine samples were collected from each patient on the first day, in the middle, and on the last day of the radiation therapy. Measurement of the bone metabolites hydroxylysylpyridinoline and lysylpyridinoline was performed by high-performance liquid chromatography. Statistical analysis was performed using the Mann–Whitney U test.

Results:

The hydroxylysylpyridinoline and lysylpyridinoline excretion decreased significantly in the combined bisphosphonate and radiotherapy group (p = 0.02, p = 0.08). No significant change of the hydroxylysylpyridinoline and lysylpyridinoline excretion was determined in the patients that received solely irradiation. Conclusion The results indicate the ability of zoledronate to prevent the early radiation-induced bone collagen degradation suggesting that the radiation-induced bone loss is mainly caused by osteoclastic bone resorption rather than by a direct radiation-induced damage (AU)
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Osteoporose / Reabsorção Óssea / Difosfonatos Tipo de estudo: Ensaio clínico controlado / Estudo de avaliação Limite: Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Mevki Military Hospital/Turkey / University Hospital Köln-Merheim/Germany / University Hospital Schleswig-Holstein/Germany
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Osteoporose / Reabsorção Óssea / Difosfonatos Tipo de estudo: Ensaio clínico controlado / Estudo de avaliação Limite: Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Mevki Military Hospital/Turkey / University Hospital Köln-Merheim/Germany / University Hospital Schleswig-Holstein/Germany
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