Toxicity of a dental adhesive compared with ionizing radiation and zoledronic acid
Med. oral patol. oral cir. bucal (Internet)
; 20(4): e427-e434, jul. 2015. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-138969
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
To determine the toxicity of aqueous dilutions of a universal self-priming dental adhesive (DA) and comparing these with those elicited by exposure to ionizing radiation (IR), Zoledronic acid (Z) treatment and the synergic effects of the combined treatment with IR+Z. MATERIAL ANDMETHODS:
The genotoxic effect of DA was determined by the increase in the frequency of micronuclei in cytokinesis-blocked in cultured human lymphocytes before and after exposure to 2Gy of X-rays. The cytotoxic effect was studied by using the MTT cell viability test in normal prostate cell lines (PNT2) after exposure to different X-ray doses (0Gy-20Gy). The cell lines divided into different groups and treated with different test substances DA in presence of O2 , DA in absence of O2 , Z-treated and control.RESULTS:
An in vitro dose-dependent and time-dependent cytotoxic effect of DA, Z and IR on PNT2 cells (p > 0.001) was demonstrated. DA without-O2, following the recommendations of manufacturers, had a more pronounced effect of increasing cell death than DA with-O2 (p < 0.001). In the genotoxicity assay, DA at 25% of its original concentration significantly increased chromosome damage (p < 0.001). The samples studied were found to be toxic, and the samples photo-polymerized in absence of O2 showed a bigger cytotoxic effect comparable to the additive toxic effect showed by the combined treatment of IR+Z.CONCLUSIONS:
Additional effort should be carried out to develop adhesives, which would reduce the release of hazardous substances; since toxic effects are similar to that reported by other agents whose clinical use is controlled by the health authoritiesRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Condições e Transtornos Bucais
Base de dados:
IBECS
Assunto principal:
Radiação Ionizante
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Radiometria
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Técnicas In Vitro
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Transformação Celular Neoplásica
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Exposição à Radiação
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Exposição a Produtos Químicos
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Cimentos Dentários
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Sinergismo Farmacológico
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Genotoxicidade
Tipo de estudo:
Guia de prática clínica
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Ghana Atomic Energy Commission Radiological and Medical Sciences Research Institute/Ghana
/
Oncology Institute of Madrid/Spain
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University of Murcia/Spain