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Comparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groups
Celiksoy, MH; Topal, E; Yıldıran, A.
Afiliação
  • Celiksoy, MH; Ondokuz Mayıs University, Medical Faculty. Departament of Pediatric Allergy an dimmunology. Samsun. Turkey
  • Topal, E; Inonu University. Medical Faculty. Departament of Pediatric, Allergy and Immunology. TurkeycMalatya
  • Yıldıran, A; Ondokuz Mayıs University, Medical Faculty. Departament of Pediatric Allergy an dimmunology. Samsun. Turkey
Allergol. immunopatol ; 43(5): 477-481, sept.-oct. 2015. tab
Artigo em Inglês | IBECS | ID: ibc-141109
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

BACKGROUND:

Ataxia telangiectasia (A-T) is a genetic disorder caused by the homozygous mutation of the A-T mutated gene. It is frequently associated with variable degrees of cellular and humoral immunodeficiency. However, the immune defects in A-T patients are not well characterized. To the best of our knowledge, no studies have focused on the major lymphocyte subpopulations and recent thymic emigrants of A-T patients in comparison with age-matched healthy controls.

METHODS:

Following the European Society for Immunodeficiencies criteria, 17 patients diagnosed with A-The, and 12 age-matched healthy children were assigned to the study. Both patients and healthy controls were grouped as 1-5, 6-10, 11-15, and 15+ years. By using a flow cytometer, major lymphocyte subpopulations and CD4+CD45RA+CD31+ recent thymic emigrants were determined as percentage and absolute cell numbers and compared.

RESULTS:

No significant differences in all lymphocyte subpopulations were observed between the age groups of A-T patients. Compared to the healthy controls, there was a decrease in T cells, effector memory T4 cells, B cells, naïve B cells, naïve T4 cells, switched B cells, and recent thymic emigrants and an increase in active T8 cells and non-switched B cells in the percentage and absolute number of some cell populations in the A-T group.

CONCLUSIONS:

This study showed that effector functions in some cell lymphocyte populations were decreased in A-T patients
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Ataxia Telangiectasia / Linfócitos B / Linfócitos T / Linfócitos T CD4-Positivos / Subpopulações de Linfócitos / Linfócitos T CD8-Positivos / Linfopenia Limite: Adolescente / Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Inonu University/TurkeycMalatya / Ondokuz Mayıs University, Medical Faculty/Turkey
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Ataxia Telangiectasia / Linfócitos B / Linfócitos T / Linfócitos T CD4-Positivos / Subpopulações de Linfócitos / Linfócitos T CD8-Positivos / Linfopenia Limite: Adolescente / Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2015 Tipo de documento: Artigo Instituição/País de afiliação: Inonu University/TurkeycMalatya / Ondokuz Mayıs University, Medical Faculty/Turkey
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