The protein kinase C (PKC) inhibitors combined with chemotherapy in the treatment of advanced non-small cell lung cancer: meta-analysis of randomized controlled trials
Clin. transl. oncol. (Print)
; 17(5): 371-377, mayo 2015. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-141718
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
The application of newer signaling pathway-targeted agents has become an important addition to chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). In this study, we evaluated the efficacy and toxicities of PKC inhibitors combined with chemotherapy versus chemotherapy alone for patients with advanced NSCLC systematically. Patients and materials Literature retrieval, trials selection and assessment, data collection, and statistic analysis were performed according to the Cochrane Handbook 5.1.0. The outcome measures were tumor response rate, disease control rate, progression-free survival (PFS), overall survival (OS), and adverse effects.Results:
Five randomized controlled trials, comprising totally 1,005 patients, were included in this study. Meta-analysis showed significantly decreased response rate (RR 0.79; 95 % CI 0.640.99) and disease control rate (RR 0.90; 95 % CI 0.820.99) in PKC inhibitors-chemotherapy groups versus chemotherapy groups. There was no significant difference between the two treatment groups regarding progression-free survival (PFS, HR 1.05; 95 % CI 0.911.22) and overall survival (OS, HR 1.00; 95 % CI 0.861.16). The risk of grade 3/4 neutropenia, leucopenia, and thrombosis/embolism increased significantly in PKC inhibitors combination groups as compared with chemotherapy alone groups.Conclusion:
The use of PKC inhibitors in addition to chemotherapy was not a valid alternative for patients with advanced NSCLCRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
Base de dados:
IBECS
Assunto principal:
Proteína Quinase C
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Carcinoma Pulmonar de Células não Pequenas
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Neoplasias Pulmonares
/
Metástase Neoplásica
Tipo de estudo:
Ensaio clínico controlado
/
Revisão sistemática
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Tianjin Medical University General Hospital/China
/
Tianjin Medical University/China