Morphological evidence of the possible relevance of aromatase P450 in autoparacrine regulation and pathology of the hypophysis
Eur. j. anat
; 19(3): 229-247, jul. 2015. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-142276
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Aromatase P450, the enzyme responsible for the catabolism of aromatizable androgens to estrogens is involved in sexual dimorphism and several pathologies induced by estrogenic effects. The present work reports evidence of pituitary aromatase synthesis, its regulation by gonadal steroids, and the physiological roles of aromatase on pituitary endocrine cells. The involvement of aromatase, through the auto-paracrine production of estradiol, in the pathogenesis of pituitary tumors -mainly prolactinomas- is reviewed
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Hipófise
/
Aromatase
/
Comunicação Parácrina
/
Sistema Enzimático do Citocromo P-450
Limite:
Humanos
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Catholic University of Salamanca/Spain
/
Complutense University of Madrid/España
/
University of Granada/Spain
/
University of Salamanca/Spain