Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine Beta-synthase in rat liver
J. physiol. biochem
; 71(4): 659-667, dic. 2015.
Artigo
em Inglês
| IBECS
| ID: ibc-145719
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Oxidative stress plays an important role in cardiovascular diseases. The study investigated the effects of dietary palm tocotrienol-rich fraction on homocysteine metabolism in rats fed a high-methionine diet. Forty-two male Wistar rats were randomly assigned to six groups. Five groups were fed with high-methionine diet (1 %) for 10 weeks. Groups 2 to 5 were also given dietary folate (8 mg/kg) and three doses of palm tocotrienol-rich fraction (30, 60 and 150 mg/kg) from week 6 to week 10. The last group was only given basal rat chow. High-methionine diet increased plasma homocysteine after 10 weeks, which was prevented by the supplementations of folate and high-dose palm tocotrienol-rich fraction. Hepatic S-adenosyl methionine (SAM) content was unaffected in all groups but S-adenosyl homocysteine (SAH) content was reduced in the folate group. Folate supplementation increased the SAM/SAH ratio, while in the palm tocotrienol-rich fraction groups, the ratio was lower compared with the folate. Augmented activity of hepatic cystathionine Beta-synthase and lipid peroxidation content by high-methionine diet was inhibited by palm tocotrienol-rich fraction supplementations (moderate and high doses), but not by folate. The supplemented groups had lower hepatic lipid peroxidation than the high-methionine diet. In conclusion, palm tocotrienol-rich fraction reduced high-methionine-induced hyperhomocysteinaemia possibly by reducing hepatic oxidative stress in high-methionine-fed rats. It may also exert a direct inhibitory effect on hepatic cystathionine Beta-synthase
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Espanha
Base de dados:
IBECS
Assunto principal:
Cistationina beta-Sintase
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Tocotrienóis
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Fígado
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Metionina
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Cyberjaya University College of Medical Sciences/Malaysia
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International Islamic University of Malaysia/Malaysia
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International Medical University/Malaysia
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Universiti Kebangsaan Malaysia/Malaysia
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Universiti Kebangsaan Malaysia/Malaysia