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Lung cancer and other second neoplasms after treatment of Hodgkin lymphoma
Almagro-Casado, E; Sánchez, A; Cantos, B; Salas, C; Pérez-Callejo, D; Provencio, M.
Afiliação
  • Almagro-Casado, E; Hospital Universitario Puerta de Hierro. Department of Medical Oncology. Majadahonda. Spain
  • Sánchez, A; Hospital Universitario Puerta de Hierro. Department of Medical Oncology. Majadahonda. Spain
  • Cantos, B; Hospital Universitario Puerta de Hierro. Department of Medical Oncology. Majadahonda. Spain
  • Salas, C; Hospital Universitario Puerta de Hierro. Department of Pathology. Majadahonda. Spain
  • Pérez-Callejo, D; Hospital Universitario Puerta de Hierro. Department of Medical Oncology. Majadahonda. Spain
  • Provencio, M; Hospital Universitario Puerta de Hierro. Department of Medical Oncology. Majadahonda. Spain
Clin. transl. oncol. (Print) ; 18(1): 99-106, ene. 2016. tab, graf
Artigo em Inglês | IBECS | ID: ibc-148058
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Purpose. To evaluate the risk factors associated with lung cancer (LC) and other second neoplasms (SN) in Hodgkin lymphoma (HL) survivors. Methods. We retrospectively analyzed the clinical characteristics and outcomes of 604 patients treated in our institution between 1968 and 2012. Results. 90 out of 604 patients developed SN 27 LC and 63 other SN. The median time elapsed until LC and other SN was 16.5 and 11.8 years, respectively (p = 0.003). In the LC group, 85.5 % of patients were male and 84.6 % smokers (HR 7, 95 % CI 2.4-20.7, p < 0.001). Radiotherapy (RT) doses applied were higher in the SN group with an increased risk of LC (HR 4.0 95 % CI 1.1-11.6, p = 0.010) and other SN (HR 3.3 95 % CI 1.6-6.7 p = 0.001) with doses higher than 42 Gy. No association was found between alkylating agents and development of SN. In LC, the most frequent histology was adenocarcinoma with an elapsed time after HL of 13.2 years in early stages and 21.3 in advanced (p = 0.02). Median OS after a diagnosis of LC was 12.6 months ranging from 5.9 (in cases presenting due to symptoms) to 49.1 (incidentally diagnosed cases) (p = 0.005). Conclusions. RT treatment, especially with doses higher than 42 Gy, and smoking increase the risk of SN after HL. In this series, LC patients with early stages had a shorter elapsed time from HL diagnosis and longer OS, therefore the role of LC screening in HL survivors should be prospectively evaluated and smoking cessation counseling ought to be a key aspect during follow-up (AU)
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Terapêutica / Doença de Hodgkin / Adenocarcinoma / Fumar / Neoplasias Pulmonares Tipo de estudo: Estudo de avaliação / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitario Puerta de Hierro/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Terapêutica / Doença de Hodgkin / Adenocarcinoma / Fumar / Neoplasias Pulmonares Tipo de estudo: Estudo de avaliação / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitario Puerta de Hierro/Spain
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