Pentoxifylline during steroid window phase at induction to remission increases apoptosis in childhood with acute lymphoblastic leukemia
Clin. transl. oncol. (Print)
; 18(4): 369-374, abr. 2016. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-150450
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Purpose:
Pentoxifylline (PTX) has been shown to increase chemotherapy-induced apoptosis. A clinical trial was developed to evaluate the effect of the addition of PTX to the induction steroid window phase in children with acute lymphoblastic leukemia (ALL).Methods:
Thirty-two children were enrolled on this study. Children with a new diagnosis of ALL were randomly assigned to receive prednisone (PRD) 40 mg/m2/day only during the 7-day treatment pre-phase (PRD group, 11 patients) or to receive PRD with PTX (10 mg/kg/day) (PTX group, 11 patients); the control group included children with normal bone marrow (10 patients). Bone marrow aspiration (BMA) was performed at diagnosis (day -7) in all groups, and at day 0 (end of PRD window) for patients with ALL (PRD and PTX groups). Apoptosis was evaluated by flow cytometry (FC) using Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) stains. Statistical analysis was performed using the MannWhitney U test.Results:
Apoptotic index at day -7 was similar in all groups. However, at day 0 post-treatment, apoptosis was significantly higher in the PTX group than in the PRD group (p < 0.001). There were no serious adverse effects associated with PTX.Conclusions:
PTX potentiates blast apoptosis induced by PRD in children with ALL during steroid window phase (AU)RESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
/
Leucemia
Base de dados:
IBECS
Assunto principal:
Pentoxifilina
/
Células da Medula Óssea
/
Prednisona
/
Fluoresceína-5-Isotiocianato
/
Apoptose
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudo:
Ensaio clínico controlado
/
Estudo de avaliação
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Mexicano del Seguro Social (IMSS)/México
/
Universidad de Guadalajara/México