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Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?
Leizaola-Cardesa, Ignacio-Osoitz; Aguilar-Salvatierra, Antonio; Gonzalez-Jaranay, Maximino; Moreu, Gerardo; Sala-Romero, María-José; Gómez-Moreno, Gerardo.
Afiliação
  • Leizaola-Cardesa, Ignacio-Osoitz; Universidad de Granada. Faculty of Dentistry. Granada. Spain
  • Aguilar-Salvatierra, Antonio; Universidad de Granada. Faculty of Dentistry. Granada. Spain
  • Gonzalez-Jaranay, Maximino; University of Granada. Faculty of Dentistry. Granada. Spain
  • Moreu, Gerardo; University of Granada. Faculty of Dentistry. Granada. Spain
  • Sala-Romero, María-José; s.af
  • Gómez-Moreno, Gerardo; University of Granada. Faculty of Dentistry. Granada. Spain
Med. oral patol. oral cir. bucal (Internet) ; 21(2): e236-e240, mar. 2016.
Artigo em Inglês | IBECS | ID: ibc-151070
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

BACKGROUND:

It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. MATERIAL AND

METHODS:

This review of literature investigates four basic parameters in patients treated with bisphosphonates - parathyroid hormone (PTH), bisphosphonates, vitamin D, calcium, and jaw osteonecrosis - which are fundamental for assessing bone metabolism and so the efficacy and correct use of the drug. The imbalances generated by vitamin D and calcium deficiencies, together with their multiple systemic repercussions, have been widely researched but the outcomes of these imbalances in relation to bisphosphonate administration are not well known, and some research has indicated that they may be associated with osteonecrosis of the jaw (ONJ).

RESULTS:

The present review set out to explain the functioning of bone metabolism, the importance of different chemical mediators, the imbalances produced by incorrect use of this drug, in order to forewarn against the possible relation of these parameters with ONJ, whose physiopathology remains unknown.

CONCLUSIONS:

Medical and dental clinics should keep detailed anamneses of the use of vitamin D and calcium supplements, as it is of vital importance to maintain their correct levels in blood, given that these are related to ONJ as well as other adverse effects; this procedure is also necessary in order to ensure the correct use of the drug
RESUMEN
No disponible
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Hormônio Paratireóideo / Vitamina D / Compostos de Cálcio / Osteonecrose da Arcada Osseodentária Associada a Difosfonatos Limite: Humanos Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Universidad de Granada/Spain / University of Granada/Spain

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Hormônio Paratireóideo / Vitamina D / Compostos de Cálcio / Osteonecrose da Arcada Osseodentária Associada a Difosfonatos Limite: Humanos Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Universidad de Granada/Spain / University of Granada/Spain
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