Defining the optimal sequence for the systemic treatment of metastatic breast cancer
Clin. transl. oncol. (Print)
; 19(2): 149-161, feb. 2017. tab
Artigo
em Inglês
| IBECS
| ID: ibc-159447
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Metastatic breast cancer is a heterogeneous disease that presents in varying forms, and a growing number of therapeutic options makes it difficult to determine the best choice in each particular situation. When selecting a systemic treatment, it is important to consider the medication administered in the previous stages, such as acquired resistance, type of progression, time to relapse, tumor aggressiveness, age, comorbidities, pre- and post-menopausal status, and patient preferences. Moreover, tumor genomic signatures can identify different subtypes, which can be used to create patient profiles and design specific therapies. However, there is no consensus regarding the best treatment sequence for each subgroup of patients. During the SABCC Congress of 2014, specialized breast cancer oncologists from referral hospitals in Europe met to define patient profiles and to determine specific treatment sequences for each one. Conclusions were then debated in a final meeting in which a relative degree of consensus for each treatment sequence was established. Four patient profiles were defined according to established breast cancer phenotypes pre-menopausal patients with luminal subtype, post-menopausal patients with luminal subtype, patients with triple-negative subtype, and patients with HER2-positive subtype. A treatment sequence was then defined, consisting of hormonal therapy with tamoxifen, aromatase inhibitors, fulvestrant, and mTOR inhibitors for pre- and post-menopausal patien ts; a chemotherapy sequence for the first, second, and further lines for luminal and triple-negative patients; and an optimal sequence for treatment with new antiHER2 therapies. Finally, a document detailing all treatment sequences, that had the agreement of all the oncologists, was drawn up as a guideline and advocacy tool for professionals treating patients with this disease (AU)
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Tamoxifeno
/
Neoplasias da Mama
/
Congressos como Assunto
/
Inibidores da Aromatase
/
Hormônios
/
Metástase Neoplásica
Tipo de estudo:
Guia de prática clínica
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Complejo Asistencial de León/Spain
/
Complejo Hospitalario Universitario de A Coruña/Spain
/
Complejo Hospitalario de Jaén/Spain
/
Complejo Hospitalario de Navarra/Spain
/
Consorcio Hospitalario i Provincial de Castellón/Spain
/
Fundación Instituto Valenciano de Oncología/Spain
/
Hospital Clínic Universitari de València/Spain
/
Hospital Santa María Nai en Ourense/Spain
/
Hospital Universitari Arnau de Vilanova/Spain
/
Hospital Universitari Vall dHebron/Spain