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Clinical and pathologic features of patients with non-epithelial ovarian cancer: retrospective analysis of a single institution 15-year experience
Kempf, E; Desamericq, G; Vieites, B; Diaz-Padilla, I; Calvo, E; Estevez, P; Garcia-Arreza, A; Martinez-Maestre, MA; Duran, I.
Afiliação
  • Kempf, E; Hospital Universitario Virgen del Rocio. Medical Oncology Department. Seville. Spain
  • Desamericq, G; Hospital Henri-Mondor. Créteil. France
  • Vieites, B; Hospital Universitario Virgen del Rocio. Department of Pathology. Seville. Spain
  • Diaz-Padilla, I; University of Seville. School of Medicine. Deanery of Doctorate Studies. Seville. Spain
  • Calvo, E; Hospital Universitario Virgen del Rocio. Medical Oncology Department. Seville. Spain
  • Estevez, P; Hospital Universitario Virgen del Rocio. Medical Oncology Department. Seville. Spain
  • Garcia-Arreza, A; Hospital Universitario Virgen del Rocio. Gynecology Department. Seville. Spain
  • Martinez-Maestre, MA; Hospital Universitario Virgen del Rocio. Gynecology Department. Seville. Spain
  • Duran, I; Hospital Universitario Virgen del Rocio. Medical Oncology Department. Seville. Spain
Clin. transl. oncol. (Print) ; 19(2): 173-179, feb. 2017. tab, graf
Artigo em Inglês | IBECS | ID: ibc-159449
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Purpose. Non-epithelial ovarian cancers (NEOCs) are rare diseases. Despite their overall good prognosis, the best management and current prognostic factors remain unclear. The objective of our study was to assess the clinical and pathological features of NEOC patients treated in our institution in the last 15 years and to explore risk factors for relapse and survival. Methods/patients. All patients with a pathological diagnosis of NEOC referred to the medical oncology department at Hospital Universitario Virgen del Rocio between 1999 and 2014 were included. Demographics, tumor characteristics, treatment procedures, and clinical follow-up were retrospectively collected. Risk factors for disease-free survival (DFS) and overall survival (OS) were assessed. Results. Fifty-seven patients were included, 33 (58 %) had a sex cord-stromal tumor (SCST) and 24 (42 %) had a germ-cell tumor (GCT). Median age, non-conservative surgery rates and DFS were lower in the GCT cohort; however, salvage chemotherapy led to a high proportion of complete responses in this group translating into a 90 % 3-year OS rate in both NEOC subtypes. The only identified risk factors statistically significant were stage and tumour relapse that associated, respectively, with DFS (HR = 8.84; 95 % CI 1.85-42) and OS (HR = 11.02; 95 % CI 1.76-68.7). Conclusions. Despite their rarity, NEOCs remain a highly curable group of neoplasm. In our series, a more conservative treatment approach in ovarian GCTs revealed comparable OS outcomes to SCST. No new risk factors that would help in patient stratification were identified (AU)
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias Ovarianas / Fatores de Risco / Neoplasias Embrionárias de Células Germinativas / Intervalo Livre de Doença / Tumores do Estroma Endometrial Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Henri-Mondor/France / Hospital Universitario Virgen del Rocio/Spain / University of Seville/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias Ovarianas / Fatores de Risco / Neoplasias Embrionárias de Células Germinativas / Intervalo Livre de Doença / Tumores do Estroma Endometrial Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Adulto / Feminino / Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Henri-Mondor/France / Hospital Universitario Virgen del Rocio/Spain / University of Seville/Spain
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