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Effect of phototherapy on B and T lymphocytes in Egyptian infants suffering from neonatal jaundice
Eyada, IK; El Saie, AL; Ibrahem, GA; Riad, NM.
Afiliação
  • Eyada, IK; Cairo University. Faculty of Medicine. Pediatrics and Neonatology Department. Egypt
  • El Saie, AL; Cairo University. Faculty of Medicine. Pediatrics and Neonatology Department. Cairo. Egypt
  • Ibrahem, GA; Shobra al Aam Hospital. Pediatric and Neonatology Department. Egypt
  • Riad, NM; Cairo University. Faculty of Medicine. Clinical and Chemical Pathology Department. Egypt
Allergol. immunopatol ; 45(3): 290-296, mayo-jun. 2017. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-162393
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

BACKGROUND:

Neonatal jaundice is one of the most common problems that affect newborn infants, and phototherapy is usually used for treatment.

OBJECTIVES:

Evaluation of the effect of phototherapy on neonatal immune system through measuring the percentage of B and T lymphocytes and determining the frequency of development of infections and need for hospitalisation during the first six months of life.

METHODS:

A prospective cohort study was conducted on 50 full term new-borns; 25 with indirect hyperbilirubinaemia and treated with conventional phototherapy and 25 healthy matched neonates as untreated controls. The percentages of CD19+, CD4+ and CD8+ lymphocytes were measured by flow cytometry before phototherapy and 72h after exposure. Follow-up of the study group for the occurrence of infections for a period of six months after phototherapy.

RESULTS:

The study showed a significant difference in CD19+ lymphocytes percentage between patients before phototherapy and controls (P value<0.01), also a significant correlation between serum levels of total bilirubin in patients and CD19+ lymphocytes percentage (P value<0.05). There was no significant difference between the percentages of CD19+, CD4+ and CD8+ lymphocytes in patients before or after 72h of exposure to phototherapy (P value>0.05). Also, there was no correlation between the percentages of CD19+, CD4+ and CD8+ lymphocytes after 72h of exposure to phototherapy and the occurrence of infections (Gastrointestinal tract and Respiratory tract infection) after six months of follow-up (P value>0.05). More studies are needed with larger number of patients to determine the effect of phototherapy on immune system
RESUMEN
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Fototerapia / Linfócitos B / Linfócitos T / Hiperbilirrubinemia / Sistema Imunitário Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Lactente / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Cairo University/Egypt / Shobra al Aam Hospital/Egypt
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Fototerapia / Linfócitos B / Linfócitos T / Hiperbilirrubinemia / Sistema Imunitário Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Lactente / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Cairo University/Egypt / Shobra al Aam Hospital/Egypt
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