Gastrointestinal stromal tumours: an actualized overview
Eur. j. anat
; 21(2): 97-112, abr. 2017. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-163135
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The gastrointestinal stromal tumour (GISTs), the most common mesenchymal neoplasm in the gastrointestinal tract, has been the subject of great interest in recent years in terms of prognosis, diagnosis and treatment. Its etiology is linked to the mutation of c-KIT and PDGFRA genes, although between 5 and 15% show no signs of such mutations. It is still diagnosed using immunohistochemical staining. The first line of treatment continues to be surgery, although advances in the molecular biology of GISTs are facilitating the development of new treatment strategies. Those that act by regulating tyrosine kinase activity are of particular interest. Drugs such as imatinib and sunitinib have improved the prognosis of these patients, although the development of resistance constitutes one of the main limitations of the treatment. The aim of this review is to present an up-to-date overview of the main etiopathogenic, diagnostic and therapeutic aspects of these tumours
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Tumores do Estroma Gastrointestinal
/
Neoplasias Gastrointestinais
/
Mesoderma
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Biosanitary Institute of Granada (ibs GRANADA)/Spain
/
Institute of Biopathology and Regenerative Medicine (IBIMER)/Spain
/
University Hospital Complex of Granada/Spain
/
University of Granada/Spain
/
University of Jaen/Spain