The role of active B cells in allergen immunotherapy
Allergol. immunopatol
; 45(5): 439-444, sept.-oct. 2017. tab
Artigo
em Inglês
| IBECS
| ID: ibc-166997
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
The purpose of this study is to examine the changes in B lymphocyte subsets in patients receiving allergen immunotherapy.Methods:
B lymphocyte subsets of patients before immunotherapy and one year after immunotherapy began were examined using the flow cytometric method. Age-matched healthy children served as the control group.Results:
Twenty-two patients with asthma and/or allergic rhinitis and 14 healthy, age-matched controls were included in the study. The median age of the patients was 13 years old (range 6-20 years), and eleven (50.0%) were male. The median age of the healthy controls was also 13 years old (range 7-17), and seven (50.0%) were male. In the age group from 11 to 15 years; the patients relative and absolute counts of active and mature sensitive B cells were higher than those of the healthy children (p = 0.027-0.012 and p = 0.032-0.010, respectively) before immunotherapy. The relative and absolute counts of active B cells before immunotherapy were also significantly higher than those of after immunotherapy (p = 0.001-0.001, p = 0.025-0.037, and p = 0.029-0.035, respectively). Before immunotherapy, the relative and absolute counts of mature sensitive B cells were significantly higher than those obtained after immunotherapy (p = 0.024-0.006) in the 1115-year-old age group.Conclusions:
Allergen immunotherapy directly influences B cell differentiation and causes a decrease in the count of active B cells. This finding is relevant because the B cell count can be used as a guide in the assessment of an individual patient's treatment response and also when determining whether to continue the immunotherapy (AU)RESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Linfócitos B
/
Imunoterapia Ativa
/
Hipersensibilidade
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Ondokuz Mayıs University/Turkey