Your browser doesn't support javascript.
loading
Effect of estrogen and/or progesterone administration on traumatic brain injury-caused brain edema: the changes of aquaporin-4 and interleukin-6
Soltani, Zahra; Khaksari, Mohammad; Shahrokhi, Nader; Mohammadi, Gholamabbas; Mofid, Behshad; Vaziri, Ali; Amiresmaili, Sedigheh.
Afiliação
  • Soltani, Zahra; Kerman University of Medical Sciences. Institute of Neuropharmacology. Physiology Research Center. Kerman. Iran
  • Khaksari, Mohammad; Kerman University of Medical Sciences. Institute of Neuropharmacology. Neuroscience Research Center. Kerman. Iran
  • Shahrokhi, Nader; Kerman University of Medical Sciences. Institute of Neuropharmacology. Physiology Research Center. Kerman. Iran
  • Mohammadi, Gholamabbas; Kerman University of Medical Sciences. Medical School of Afzalipour. Department of Biochemistry. Kerman. Iran
  • Mofid, Behshad; Shahid Bahonar Hospital of Kerman. Department of Neurosurgery. Kerman. Iran
  • Vaziri, Ali; Kerman University of Medical Sciences. Medical School of Afzalipour. Department of Biochemistry. Kerman. Iran
  • Amiresmaili, Sedigheh; Bam University of Medical Sciences. Kerman. Iran
J. physiol. biochem ; 72(1): 33-44, mar. 2016. graf
Artigo em Inglês | IBECS | ID: ibc-168205
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
The role of aquaporin-4 (AQP4) and interleukin-6 (IL-6) in the development of brain edema post-traumatic brain injury (TBI) has been indicated. The present study was designed to investigate the effect(s) of administration of progesterone (P) and/or estrogen (E) on brain water content, AQP4 expression, and IL-6 levels post-TBI. The ovariectomized rats were divided into 11 groups sham, one vehicle, two vehicles, E1, E2, P1, P2, E1 + P1, E1 + P2, E2 + P1, and E2 + P2. The brain AQP4 expression, IL-6 levels, and water content were evaluated 24 h after TBI induced by Marmarou’s method. The low (E1 and P1) and high (E2 and P2) doses of estrogen and progesterone were administered 30 min post-TBI. The results showed that brain water content and AQP4 expression decreased in the E1, E2, P1, and P2-treated groups. The administration of E1 decreased IL-6 levels. Addition of progesterone decreased the inhibitory effect of E1 and E2 on the accumulation of water in the brain. Administration of E1 + P1 and E1 + P2 decreased the inhibitory effect of E1 on the IL-6 levels and AQP4 protein expression. Our findings suggest that estrogen or progesterone by itself has more effective roles in decrease of brain edema than combination of both. Possible mechanism may be mediated by the alteration of AQP4 and IL-6 expression. However, further studies are required to verify the exact mechanism (AU)
RESUMEN
No disponible
Assuntos
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Progesterona / Edema Encefálico / Lesões Encefálicas / Interleucina-6 / Estrogênios / Aquaporina 4 Limite: Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Bam University of Medical Sciences/Iran / Kerman University of Medical Sciences/Iran / Shahid Bahonar Hospital of Kerman/Iran
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Progesterona / Edema Encefálico / Lesões Encefálicas / Interleucina-6 / Estrogênios / Aquaporina 4 Limite: Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Bam University of Medical Sciences/Iran / Kerman University of Medical Sciences/Iran / Shahid Bahonar Hospital of Kerman/Iran
...