Histological effects of bisphenol-A on the reproductive organs of the adult male albino rat
Eur. j. anat
; 22(2): 89-102, mar. 2018. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-172183
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Bisphenol-A (BPA) is widely used in the environment. The objective of this study was to investigate the histological reproductive toxicity of BPA in the adult male albino rats. Forty-five adult male albino rats were divided into 3 groups. Group I received normal saline orally daily (negative control); Group II received corn oil (0.5 ml/day) orally daily (positive control, and Group III were treated with BPA in a dose of 25 mg/kg B.W dissolved in corn oil for 30 days orally. Specimens from the testis, epididymis, prostate and seminal vesicles were collected for light microscopic examination. Blood samples were collected for serum testosterone level assessment. BPA caused histopathological alterations in the epithelium and connective tissues of all organs. Results of the serum testosterone level statistical analysis showed a highly significant decrease in BPA-treated group (III) as compared to the control groups (I & II). The epithelium of the accessory sex glands (prostate and seminal vesicles) responds to BPA by proliferative differentiation. The mean area percentage of collagen fibers stained with Masson's trichrome measured in the stroma of all organs was significantly increased. Also, there was a significant increase in the area percentage of positive inducible nitric oxide synthase (iNOS) immunoreactions in all organs. In conclusion, BPA induced DNA oxidative damage via iNOS activity in all reproductive organs
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Próstata
/
Glândulas Seminais
/
Testículo
/
Bis-Fenol A-Glicidil Metacrilato
/
Fenômenos Reprodutivos Fisiológicos
Limite:
Animais
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Zagazig University/Egyp