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Virgin coconut oil and diabetic wound healing: histopathological and biochemical analysis
Soliman, Amro M; Lin, Teoh S; Ghafar, Norzana A; Das, Srijit.
Affiliation
  • Soliman, Amro M; Universiti Kebangsaan Malaysia Medical Centre. Department of Anatomy. Kuala Lumpur. Malaysia
  • Lin, Teoh S; Universiti Kebangsaan Malaysia Medical Centre. Department of Anatomy. Kuala Lumpur. Malaysia
  • Ghafar, Norzana A; Universiti Kebangsaan Malaysia Medical Centre. Department of Anatomy. Kuala Lumpur. Malaysia
  • Das, Srijit; Universiti Kebangsaan Malaysia Medical Centre. Department of Anatomy. Kuala Lumpur. Malaysia
Eur. j. anat ; 22(2): 135-144, mar. 2018. graf, ilus
Article in English | IBECS | ID: ibc-172188
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Delayed wound healing (the diabetic ulcer) is one of the major complications of diabetes mellitus (DM), which has shown an increasing trend over previous decades to affect almost 15% of diabetic patients. Virgin coconut oil (VCO) is a natural oil rich in vitamins and antioxidants and possesses antimicrobial and antiviral activities. In the current study, we evaluated the effects of topical application of VCO on wound healing in diabetes-induced Sprague-Dawley rats. A total of 72 animals were divided into 4 groups i.e. (I) non-diabetic nontreated (NN), (II) diabetic non-treated (DN), (III) diabetic treated with VCO (VCO), and (IV) diabetic treated with silver sulfadiazine cream (SS). Wounds were inflicted on all groups using punch biopsy needles, and the animals were treated for 14 days. Wound closure rate (WCR) was measured on day 5, 10, and 14. Histological analysis was performed on day 7 and 14. Total protein content and superoxide dismutase (SOD) activity were measured on day 1, 7, and 14. WCR in VCO group was higher on all days compared to DN. Histological analysis revealed that VCO promoted re-epithelialization and increased collagen content of wound tissue. Total protein content in VCO group was higher on day 7 and 14 compared to both DN and SS groups. VCO showed insignificant effects on SOD levels. In summary, VCO was found to be better than silver sulfadiazine cream in the healing of diabetic wounds via promoting reepithelialization and collagen synthesize as well as increasing WCR and total protein content
RESUMEN
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Subject(s)
Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Wound Healing / Wounds and Injuries / Blood Glucose / Palm Oil / Foot Ulcer / Diabetic Foot Type of study: Diagnostic study Limits: Animals Language: English Journal: Eur. j. anat Year: 2018 Document type: Article Institution/Affiliation country: Universiti Kebangsaan Malaysia Medical Centre/Malaysia
Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Wound Healing / Wounds and Injuries / Blood Glucose / Palm Oil / Foot Ulcer / Diabetic Foot Type of study: Diagnostic study Limits: Animals Language: English Journal: Eur. j. anat Year: 2018 Document type: Article Institution/Affiliation country: Universiti Kebangsaan Malaysia Medical Centre/Malaysia
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