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Prognostic value of change in anti-thyroglobulin antibodies after thyroidectomy in patients with papillary thyroid carcinoma
Ernaga-Lorea, A; Hernández-Morhain, MC; Anda-Apiñániz, E; Pineda-Arribas, J; Migueliz-Bermejo, I; Eguílaz-Esparza, N; Irigaray-Echarri, A.
Afiliação
  • Ernaga-Lorea, A; Complejo Hospitalario de Navarra. Department of Endocrinology. Pamplona. Spain
  • Hernández-Morhain, MC; Hospital Central de la Defensa Gómez Ulla. Department of Endocrinology. Madrid. Spain
  • Anda-Apiñániz, E; Complejo Hospitalario de Navarra. Department of Endocrinology. Pamplona. Spain
  • Pineda-Arribas, J; Complejo Hospitalario de Navarra. Department of Endocrinology. Pamplona. Spain
  • Migueliz-Bermejo, I; Complejo Hospitalario de Navarra. Department of Endocrinology. Pamplona. Spain
  • Eguílaz-Esparza, N; Complejo Hospitalario de Navarra. Department of Endocrinology. Pamplona. Spain
  • Irigaray-Echarri, A; Complejo Hospitalario de Navarra. Department of Endocrinology. Pamplona. Spain
Clin. transl. oncol. (Print) ; 20(6): 740-744, jun. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-173622
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Purpose:

Anti-thyroglobulin antibodies (TgAb) can be used as a surrogate tumor marker in the follow-up of papillary thyroid carcinoma (PTC). We try to determine if the change in TgAb levels in the first post-operative year is a good predictor of persistence/recurrence risk in TgAb-positive PTC patients. Methods/patients 105 patients with PTC who underwent thyroidectomy between 1988 and 2014 were enrolled. We calculated the percentage of change in TgAb levels with the first measurement at 1-2 months after surgery and the second one at 12-14 months.

Results:

TgAb negativization was observed in 29 patients (27.6%), a decrease of more than 50% was observed in 57 patients (54.3%), less than 50% in 12 patients (11.4%) and in 7 patients (6.7%) the TgAb level had increased. The percentage of persistence/recurrence was 0, 8.8, 16.7 and 71.4% in each group, respectively (p < 0.001). In the multivariate analysis, only the percentage of change in TgAb showed a significant association with the risk of persistence/recurrence, regardless of other factors such as age, size and TNM stages.

Conclusions:

Changes in TgAb levels in the first year after surgery can predict the risk of persistence/recurrence of TgAb-positive PTC patients. Patients who achieved negativization of TgAb presented an excellent prognosis
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Tireoidectomia / Neoplasias da Glândula Tireoide / Carcinoma Papilar Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Complejo Hospitalario de Navarra/Spain / Hospital Central de la Defensa Gómez Ulla/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Tireoidectomia / Neoplasias da Glândula Tireoide / Carcinoma Papilar Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Complejo Hospitalario de Navarra/Spain / Hospital Central de la Defensa Gómez Ulla/Spain
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