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Comparative analysis of the effect of different radiotherapy regimes on lymphocyte and its subpopulations in breast cancer patients
Yuan, C; Wang, Q.
Afiliação
  • Yuan, C; Qilu Hospital of Shandong University. Cancer Research Center. Jinan. China
  • Wang, Q; Qilu Hospital of Shandong University. Cancer Research Center. Jinan. China
Clin. transl. oncol. (Print) ; 20(9): 1219-1225, sept. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-173708
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Purpose:

The aim of this study was to determine whether different radiotherapy (RT) fractionation schemes induce disparate effects on lymphocyte and its subsets in breast cancer patients.

Methods:

60 female patients diagnosed with breast cancer were recruited in this study after receiving modified radical mastectomy and were randomly divided into two groups. One group received irradiation at a standard dose of 50 Gy in 25 fractions and the other at a dose of 40.3 Gy in 13 fractions. Both total lymphocyte count and its composition were recorded at three timepoints right before the radiation treatment (T0), immediately after the last fraction of radiotherapy (T1) and 6 months after irradiation therapy ended (T2).

Results:

Both groups experienced temporal lymphopenia after finishing local radiation (T1) (13F T0 vs. T1 1570.6 ± 243.9 vs. 940.6 ± 141.8, **p < 0.01; 25F T0 vs. T1 1620.5 ± 280.2 vs. 948.5 ± 274.6, **p < 0.01), while the lymphocyte count recovered at follow-up time (T2), and the cell count in the hypofractionation group (13F) was higher than the standard fraction group (25F) (13F vs. 25F 1725.6 ± 225.6 vs. 1657.5 ± 242.4, *p < 0.05). With respect to the composition of lymphocyte, we found T cell, B cell, and NK cell reacted differently to different radiotherapy protocols.

Conclusions:

Different RT protocols impose different impacts on immunity, leading us to further explore the optimal radiotherapy regimes to synergy with immunotherapy
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Radioterapia / Neoplasias da Mama / Linfócitos / Subpopulações de Linfócitos Tipo de estudo: Guia de prática clínica Limite: Feminino / Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Qilu Hospital of Shandong University/China
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Radioterapia / Neoplasias da Mama / Linfócitos / Subpopulações de Linfócitos Tipo de estudo: Guia de prática clínica Limite: Feminino / Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Qilu Hospital of Shandong University/China
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