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Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas
González-Galván, María del Carmen; Mosqueda-Taylor, Adalberto; Bologna-Molina, Ronell; Setien-Olarra, Amaia; Marichalar-Mendia, Xabier; Aguirre-Urizar, José-Manuel.
Afiliação
  • González-Galván, María del Carmen; National University of Asunción. Faculty of Dentistry. Paraguay
  • Mosqueda-Taylor, Adalberto; Universidad Autónoma Metropolitana Xochimilco. Health Care Department. Ciudad de México. México
  • Bologna-Molina, Ronell; University of the Republic (UDELAR). Faculty of Dentistry. Uruguay
  • Setien-Olarra, Amaia; University of the Basque Country (UPV/EHU). Faculty of Medicine and Nursing. Department of Stomatology II. Leioa. Spain
  • Marichalar-Mendia, Xabier; University of the Basque Country (UPV/EHU). Faculty of Medicine and Nursing. Department of Stomatology II. Leioa. Spain
  • Aguirre-Urizar, José-Manuel; University of the Basque Country (UPV/EHU). Faculty of Medicine and Nursing. Department of Stomatology II. Leioa. Spain
Med. oral patol. oral cir. bucal (Internet) ; 23(3): e315-e319, mayo 2018. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-175883
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

BACKGROUND:

Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANK-L / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth.

OBJECTIVES:

To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. MATERIAL AND

METHODS:

Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANK-L and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data.

RESULTS:

There are significant differences in the expression of RANK in OM samples as compared to DF (p= 0.022) and among the OMSs and OMLs (p= 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples.

CONCLUSIONS:

Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Osteogênese / Tumores Odontogênicos / Ligante RANK / Receptor Ativador de Fator Nuclear kappa-B / Mixoma Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: National University of Asunción/Paraguay / Universidad Autónoma Metropolitana Xochimilco/México / EHU)+Spain / University of the Republic (UDELAR)/Uruguay

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Osteogênese / Tumores Odontogênicos / Ligante RANK / Receptor Ativador de Fator Nuclear kappa-B / Mixoma Tipo de estudo: Fatores de risco Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: National University of Asunción/Paraguay / Universidad Autónoma Metropolitana Xochimilco/México / EHU)+Spain / University of the Republic (UDELAR)/Uruguay
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