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Association of a cholesteryl ester transfer protein variant (rs1800777) with fat mass, HDL cholesterol levels, and metabolic syndrome / Asociación de la variante (rs1800777) de proteína de transferencia de ésteres de colesterol con masa grasa, niveles de colesterol HDL y síndrome metabólico
Luis, Daniel de; Izaola, Olatz; Primo, David; Gomez, Emilia; Lopez, Juan Jose; Ortola, Ana; Aller, Rocio.
Afiliação
  • Luis, Daniel de; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Izaola, Olatz; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Primo, David; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Gomez, Emilia; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Lopez, Juan Jose; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Ortola, Ana; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Aller, Rocio; University of Valladolid. Hospital Clínico Universitario. Medicine School. Department of Endocrinology and Investigation. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
Endocrinol. diabetes nutr. (Ed. impr.) ; 65(7): 387-393, ago.-sept. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-176124
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Background:

There is little evidence of the association between CETP SNPs and obesity and/or related metabolic parameters.

Objective:

To analyze the association of the polymorphism rs1800777 of the CETP gene with anthropometric parameters, lipid profile, metabolic syndrome and its components, and adipokine levels in obese subjects without type 2 diabetes mellitus or hypertension.

Design:

A population of 1005 obese subjects was analyzed. Electrical bioimpedance was performed, and blood pressure, presence of metabolic syndrome, dietary intake, physical activity, and biochemical tests were recorded.

Results:

Nine hundred and sixty eight patients (96.3%) had the GG genotype, 37 patients the GA genotype (3.7%) (no AA genotype was detected). Fat mass (delta 4.4±1.1kg; p=0.04), waist circumference (delta 5.6±2.1cm; p=0.02), and waist to hip ratio (delta 0.04±0.01cm; p=0.01) were higher in A allele carriers than in non-A allele carriers. HDL cholesterol levels were lower in A allele carriers than in non-A allele carriers (delta 4.2±1.0mg/dL; p=0.04). In the logistic regression analysis, the GA genotype was associated to an increased risk of central obesity (OR 7.55, 95% CI 1.10-55.70, p=0.02) and low HDL cholesterol levels (OR 2.46, 95% CI 1.23-4.91, p=0.014).

Conclusion:

The CETP variant at position +82 is associated to lower HDL cholesterol levels, increased fat mass, and central obesity in obese subjects. These results may suggest a potential role of this variant gene in pathophysiology of adipose tissue
RESUMEN
Antecedentes Existen pocas evidencias en relación a la asociación entre los SNP de CETP y la presencia de obesidad y/o parámetros metabólicos relacionados.

Objetivo:

Examinar la asociación del polimorfismo (rs1800777) del gen CETP con parámetros antropométricos, perfil lipídico, presencia de síndrome metabólico y sus diferentes componentes y los niveles de adipocitoquinas en sujetos con obesidad sin diabetes mellitus ni hipertensión.

Diseño:

Se analizó una población de 1.005 sujetos con obesidad. Se registró una bioimpedancia, presión arterial, presencia de síndrome metabólico, ingesta dietética, ejercicio físico y parámetros bioquímicos.

Resultados:

Novecientos sesenta y ocho pacientes (96,3%) tuvieron el genotipo GG y 37 pacientes presentaron el genotipo GA (3,7%) (no se detectó genotipo AA). La masa grasa (delta 4,4±1,1kg; p=0,04), circunferencia de la cintura (delta 5,6±2,1cm; p=0,02), relación cintura-cadera (delta 0,04±0,01cm; p=0,01) fueron mayores en los portadores del alelo A. El colesterol HDL fue menor en los portadores del alelo A (delta 4,2±1,0mg/dl; p=0,04). En el análisis de regresión logística la presencia del alelo A se asoció con un mayor riesgo de obesidad central (OR 7,55; IC 95% 1,10-55,70; p=0,02) y un mayor riesgo de colesterol HDL bajo (OR 2,46; IC 95% 1,23-4,91; p=0,014).

Conclusión:

La variante CETP en la posición +82 se asocia a unos niveles más bajos de colesterol HDL, a un mayor porcentaje de masa grasa y obesidad central en personas con obesidad. Estos resultados podrían sugerir un posible papel de esta variante en la fisiopatología del tejido adiposo
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Síndrome Metabólica / Proteínas de Transferência de Ésteres de Colesterol / HDL-Colesterol Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Endocrinol. diabetes nutr. (Ed. impr.) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: University of Valladolid/Spain

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Síndrome Metabólica / Proteínas de Transferência de Ésteres de Colesterol / HDL-Colesterol Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Endocrinol. diabetes nutr. (Ed. impr.) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: University of Valladolid/Spain
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