Trazodone utilization among the elderly in Spain. A population based study / Utilización de trazodona en ancianos. Un estudio de base poblacional
Rev. psiquiatr. salud ment. (Barc., Ed. impr.)
; 11(4): 208-215, oct.-dic. 2018. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-176754
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Introduction:
Trazodone was authorized for the treatment of depression in the 1970s. Several additional therapeutic uses have been proposed due to its heterogeneous mechanism. This study aims to determine the use of trazodone in the elderly in Spain.Methods:
A nationwide, longitudinal and descriptive analysis was conducted using data from patients aged >65 years with a first prescription of trazodone during the period 2002-2011. Information on dose, comorbidities and relevant co-medication was gathered from the Spanish Primary Care database BIFAP. Incidence rates of trazodone use per 10,000 person-years were calculated by sex and age.Results:
A total of 11,766 patients receiving a first prescription of trazodone were included. The incidence rate of trazodone use was 47.2 (95% CI 46.33-48.04) per 10,000 person-years. An increasing trend in the use of trazodone was observed (5-fold increase in 2011 as compared to 2002). The most common therapeutic indications were depression (21.41%), Alzheimer/dementia (20.36%), sleep disorders (16.22%), and anxiety disorder (8.91%). The median dose was 100mg/day. The use of trazodone concomitantly with interacting medicines was frequent anti-hypertensives (53.60%), and CNS depressors (59.32%).Conclusions:
Trazodone use is increasing in elderly patients, and a high proportion of use in non-approved indications was observed. Trazodone is not being used at high doses, but interacting medicines were frequent, and it may pose additional risks for elderly patients
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Trazodona
/
Aprovação de Drogas
/
Ensaios de Uso Compassivo
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. psiquiatr. salud ment. (Barc., Ed. impr.)
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Ministry of Finance and Public Administrations/Spain
/
Spanish Agency of Medicines and Medical Devices (AEMPS)/Spain