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Trazodone utilization among the elderly in Spain. A population based study / Utilización de trazodona en ancianos. Un estudio de base poblacional
Macías Saint-Gerons, Diego; Huerta Álvarez, Consuelo; García Poza, Patricia; Montero Corominas, Dolores; Fuente Honrubia, César de la.
Afiliação
  • Macías Saint-Gerons, Diego; Spanish Agency of Medicines and Medical Devices (AEMPS). Division of Pharmacoepidemiology and Pharmacovigilance. Madrid. Spain
  • Huerta Álvarez, Consuelo; Spanish Agency of Medicines and Medical Devices (AEMPS). Division of Pharmacoepidemiology and Pharmacovigilance. Madrid. Spain
  • García Poza, Patricia; Spanish Agency of Medicines and Medical Devices (AEMPS). Division of Pharmacoepidemiology and Pharmacovigilance. Madrid. Spain
  • Montero Corominas, Dolores; Spanish Agency of Medicines and Medical Devices (AEMPS). Division of Pharmacoepidemiology and Pharmacovigilance. Madrid. Spain
  • Fuente Honrubia, César de la; Ministry of Finance and Public Administrations. Area of Budgetary Stability. Madrid. Spain
Rev. psiquiatr. salud ment. (Barc., Ed. impr.) ; 11(4): 208-215, oct.-dic. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-176754
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Introduction:

Trazodone was authorized for the treatment of depression in the 1970s. Several additional therapeutic uses have been proposed due to its heterogeneous mechanism. This study aims to determine the use of trazodone in the elderly in Spain.

Methods:

A nationwide, longitudinal and descriptive analysis was conducted using data from patients aged >65 years with a first prescription of trazodone during the period 2002-2011. Information on dose, comorbidities and relevant co-medication was gathered from the Spanish Primary Care database BIFAP. Incidence rates of trazodone use per 10,000 person-years were calculated by sex and age.

Results:

A total of 11,766 patients receiving a first prescription of trazodone were included. The incidence rate of trazodone use was 47.2 (95% CI 46.33-48.04) per 10,000 person-years. An increasing trend in the use of trazodone was observed (5-fold increase in 2011 as compared to 2002). The most common therapeutic indications were depression (21.41%), Alzheimer/dementia (20.36%), sleep disorders (16.22%), and anxiety disorder (8.91%). The median dose was 100mg/day. The use of trazodone concomitantly with interacting medicines was frequent anti-hypertensives (53.60%), and CNS depressors (59.32%).

Conclusions:

Trazodone use is increasing in elderly patients, and a high proportion of use in non-approved indications was observed. Trazodone is not being used at high doses, but interacting medicines were frequent, and it may pose additional risks for elderly patients
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Trazodona / Aprovação de Drogas / Ensaios de Uso Compassivo Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. psiquiatr. salud ment. (Barc., Ed. impr.) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Ministry of Finance and Public Administrations/Spain / Spanish Agency of Medicines and Medical Devices (AEMPS)/Spain

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Trazodona / Aprovação de Drogas / Ensaios de Uso Compassivo Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. psiquiatr. salud ment. (Barc., Ed. impr.) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Ministry of Finance and Public Administrations/Spain / Spanish Agency of Medicines and Medical Devices (AEMPS)/Spain
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