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Role of the PNPLA3 polymorphism rs738409 on silymarin + vitamin E response in subjects with non-alcoholic fatty liver disease
Aller, Rocío; Laserna, Cristina; Rojo, Miguel Ángel; Mora, Natalia; García Sánchez, Concepción; Pina, María; Sigüenza, Rebeca; Durà, Miguel; Primo, David; Izaola, Olatz; Luis, Daniel de.
Afiliação
  • Aller, Rocío; Hospital Clínico Universitario. Department of Gastroenterology. Valladolid. Spain
  • Laserna, Cristina; Hospital Clínico Universitario. Family and Community Medicine. Valladolid. Spain
  • Rojo, Miguel Ángel; Universidad de Valladolid. Medicine School. Valladolid. Spain
  • Mora, Natalia; Hospital Clínico Universitario. Department of Gastroenterology. Valladolid. Spain
  • García Sánchez, Concepción; Hospital Clínico Universitario. Department of Gastroenterology. Valladolid. Spain
  • Pina, María; Hospital Clínico Universitario. Department of Radiology. Valladolid. Spain
  • Sigüenza, Rebeca; Hospital Clínico Universitario. Department of Radiology. Valladolid. Spain
  • Durà, Miguel; Hospital Clínico Universitario. Department of Gastroenterology. Valladolid. Spain
  • Primo, David; Universidad de Valladolid. Department of Endocrinology and Nutrition Medicine School. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Izaola, Olatz; Universidad de Valladolid. Department of Endocrinology and Nutrition Medicine School. Center of Investigation of Endocrinology and Nutrition. Valladolid. Spain
  • Luis, Daniel de; Universidad de Valladolid. Medicine School. Valladolid. Spain
Rev. esp. enferm. dig ; 110(10): 634-640, oct. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-177819
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Background:

non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries. Lifestyle changes are the pillar of the treatment, although a pharmacological approach is sometimes required in the case of a failure to respond/adhere to the diet.

Objective:

the aim of this study was to evaluate the effect of silymarin and the influence of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant on the response to treatment in patients with NAFLD in a pilot study.

Methods:

a total of 54 patients with a NAFLD proven biopsy were enrolled in an open prospective study and were treated with Eurosil 85(R) (silymarin + vitamin E) for six months. Biochemical parameters and cardiovascular risk factors (diabetes mellitus, dyslipidemia, hypertriglyceridemia, arterial hypertension and HOMA-IR > 2.5) were recorded before and after six months of treatment. Non-invasive indexes (fatty liver index, lipid accumulation product and NAFLD-fibrosis score) were also calculated. The rs738409 PNPLA3 gene polymorphism status was also determined.

Results:

significant statistical changes from baseline values after six months of treatment were observed in transaminases levels but not in non-invasive index markers. Twenty patients (37.1%) were G allele carriers and had a higher percentage of lobular inflammation and ballooning on the basal liver biopsy. Patients with the G allele had a smaller decrease in transaminases levels after treatment with silymarin + vitamin E than non-G-allele carriers.

Conclusions:

treatment with silymarin + vitamin E produced a decrease in transaminases after six months of treatment without an accompanying weight loss. PNPLA3 G-allele carriers responded poorly to the treatment
RESUMEN
No disponible
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Fosfolipases / Silimarina / Vitamina E / Fígado Gorduroso Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. esp. enferm. dig Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Clínico Universitario/Spain / Universidad de Valladolid/Spain

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Fosfolipases / Silimarina / Vitamina E / Fígado Gorduroso Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. esp. enferm. dig Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Clínico Universitario/Spain / Universidad de Valladolid/Spain
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