Is vitamin D level associated with the natural course of atopic dermatitis?
Allergol. immunopatol
; 46(6): 546-551, nov.-dic. 2018. tab
Artigo
em Inglês
| IBECS
| ID: ibc-177893
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
INTRODUCTION AND OBJECTIVES:
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. Apart from its well-known role on calcium metabolism, vitamin D is reported to affect skin functions. The study aims were to compare the vitamin D levels of children with AD and healthy children; investigate the relationship between the severity of AD and vitamin D levels; and investigate the effect of vitamin D on the natural course of AD. Patients or materials andmethods:
Sixty-nine patients with AD were enrolled. Seventy healthy children were assigned as control group. Clinical and demographic features of groups were recorded. The skin prick test, eosinophil counts, immunoglobulin (Ig) E levels and serum 25 OH cholecalciferol (25OHD3) levels were measured. After at least 4 years of follow-up, patients were re-evaluated for natural course of AD.RESULTS:
Mean 25OHD3 level was lower in patient group vs. control group; 19.86 ± 6.7 ng/mL (min-max 6.8-40) vs. 24.07 ± 9.08 ng/mL, respectively, (p = 0.002). Mean 25OHD3 levels, and vitamin D status were significantly different between AD severity groups. (p < 0.05). In terms of vitamin D status in the pairwise comparison, vitamin D deficiency was greater in children with severe and moderate AD groups (respectively, p = 0.005, p = 0.018). In Tukey's post hoc analysis for 25OHD3 level, the 25OHD3 levels of severe AD are significantly lower than mild or moderate AD (respectively, p = 0.001, p = 0.026). There was a negative correlation between 25OHD3 levels and severity of AD (r = -0.480; p =0.001). In patients reassessed after 4 years age, the age of AD onset, vitamin D deficiency, SCORAD level and severe AD were higher in the persistent group vs. remission group, 25OHD3 levels were higher in the remission group vs. persistent group (p < 0.05).CONCLUSIONS:
Mean vitamin D levels were lower in patients with AD. A negative correlation between vitamin D levels and disease severity was documented. Vitamin D may affect the natural course of atopic dermatitis. There is a need for more comprehensive studies in this regardRESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Dermatite Atópica
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Health Sciences University/Turkey