Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells
J. physiol. biochem
; 73(3): 445-455, ago. 2017. graf, tab
Artigo
em Inglês
| IBECS
| ID: ibc-178895
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-alfa and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Dieta Mediterrânea
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Diabetes Mellitus Tipo 2
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Transcriptoma
/
Leucócitos
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital del Mar/Spain
/
Institute of Health Carlos III/Spain
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Madrid Institute of Advance Studies (IMDEA)/Spain
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Universidad de Navarra/Spain
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Universitat Rovira i Virgili/Spain
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University of Barcelona/Spain
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University of Valencia/Spain