Effects of reactive oxygen species and interplay of antioxidants during physical exercise in skeletal muscles
J. physiol. biochem
; 74(3): 359-367, ago. 2018. graf
Artigo
em Inglês
| IBECS
| ID: ibc-178991
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
A large number of researches have led to a substantial growth of knowledge about exercise and oxidative stress. Initial investigations reported that physical exercise generates free radical-mediated damages to cells; however, in recent years, studies have shown that regular exercise can upregulate endogenous antioxidants and reduce oxidative damage. Yet, strenuous exercise perturbs the antioxidant system by increasing the reactive oxygen species (ROS) content. These alterations in the cellular environment seem to occur in an exercise type-dependent manner. The source of ROS generation during exercise is debatable, but now it is well established that both contracting and relaxing skeletal muscles generate reactive oxygen species and reactive nitrogen species. In particular, exercises of higher intensity and longer duration can cause oxidative damage to lipids, proteins, and nucleotides in myocytes. In this review, we summarize the ROS effects and interplay of antioxidants in skeletal muscle during physical exercise. Additionally, we discuss how ROS-mediated signaling influences physical exercise in antioxidant system
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Exercício Físico
/
Traumatismo por Reperfusão
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Músculo Esquelético
/
Estilo de Vida Saudável
/
Antioxidantes
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidade do Extremo Sul Catarinense/Brazil