The effect of bupropion on sexual function in patients with Schizophrenia: A randomized clinical trial

ABSTRACT

Background and objective: About one percent of the world's population are affected by Schizophrenia. It is assumed that antipsychotic drugs cause sexual dysfunction, but the main mechanism of it, is not specified. Few researches that have addressed this issue showed that there is a relationship between neuroleptics and sexual dysfunction. A number of studies found that bupropion could improve the sexual dysfunction. So the purpose of this study is to investigate the effect of bupropion on sexual function of the patients with Schizophrenia. Methods: This randomized clinical trial was performed on 40 schizophrenic patients admitted to Kamrani psychiatry clinic in Tehran during 2015-2016. Participants were randomly divided into two experimental and control groups. The experiment group was taken bupropion tablets 150 mg/day and the control group were given placebo for one-month. The sexual performance of participants was studied before and after the intervention by the sexual functioning questionnaire (SFQ). Obtained data were analyzed using the SPSS software with student t-test and chi-square tests. Results: 40 patients older than 18 year old participated in the study. Before treatment the two groups did not have significant difference based on a general score of SFQ questionnaire, but There was a significant difference between two groups after the intervention. Experiment group (bupropion) showed significant improvement in sexual function. Using bupropion in the experiment group led to significant change in the score of sexual desire, erection and orgasm, but it had no effect on sexual arousal and ejaculation. The associations of ejaculation and orgasm were significance. Using the bupropion changed the erection and orgasm in the two groups of control and experimental. Conclusion: This study shows that 150 mg/day dose have considerable effect on sexual dysfunction of patients that are under treatment with anti-psychotic drugs. Also, this drug does not have any special side effects

RESUMEN

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