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Increased IRF4 expression in isolated B cells from common variable immunodeficiency (CVID) patients
Afshar-Ghasemlou, S; Esmaeil, N; Sherkat, R; Yazdani, R; Abbasi-Rad, F; Ganjalikhani-Hakemi, M; Rezaei, A.
Afiliação
  • Afshar-Ghasemlou, S; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Esmaeil, N; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Sherkat, R; Isfahan University of Medical Sciences. Acquired Immunodeficiency Research Center. Isfahan. Iran
  • Yazdani, R; Tehran University of Medical Science. Children's Medical Center. Research Center for Immunodeficiencies, Pediatrics Center of Excellence. Tehran. Iran
  • Abbasi-Rad, F; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Ganjalikhani-Hakemi, M; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Rezaei, A; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
Allergol. immunopatol ; 47(1): 52-59, ene.-feb. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-180772
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Background:

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by low serum levels of immunoglobulins (Igs) and recurrent infection. In most CVID patients, a defect in the differentiation of B cells into plasma cells has been observed. Several factors play an important role in the proliferation and differentiation of B cells, including IRF4 and XBP1 transcription factors.

Methods:

In the present study we investigated the expression of IRF4 and XBP1 in the B-cells of CVID and healthy controls (HCs). For this purpose, we assessed the expression of IRF4 and XBP1 at both mRNA and protein levels by real time-PCR and flow cytometry, respectively.

Results:

We found that IRF4 expression was significantly increased in CVID patients compared with controls. Although the XBP1 protein level was lower in patients in comparison to controls, this difference was not significant.

Conclusion:

Taken together, increased IRF4 expression could be involved in defective functions of B cells in CVID patients
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Linfócitos B / Imunodeficiência de Variável Comum / Fatores Reguladores de Interferon Limite: Adolescente / Criança / Criança, pré-escolar / Humanos / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Isfahan University of Medical Sciences/Iran / Tehran University of Medical Science/Iran
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Linfócitos B / Imunodeficiência de Variável Comum / Fatores Reguladores de Interferon Limite: Adolescente / Criança / Criança, pré-escolar / Humanos / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Isfahan University of Medical Sciences/Iran / Tehran University of Medical Science/Iran
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