Heavy metals obtained from waterways induced neurodegeneration in the prefrontal cortex of Wistar rats
Eur. j. anat
; 23(1): 65-76, ene. 2019. ilus, tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-181632
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The level of heavy metals in Nigeria waterways is grossly influenced by the irrepressible disposal and recycling of electronic waste. The impact of heavy metals obtained from waterways on the prefrontal cortex of experimental rats was investigated in this study. Thirty (30) adult male Wistar rats weighing about 150-180 g were used in this study. Ten rats apiece were assigned randomly into three groups. Pooled sampled water and water containing the highest average concentration of combined heavy metals recorded in the waterways was given to the Wistar rats within the treatment groups ad libitum for 65 days. Blood sera were obtained for analysis of oxidative stress markers. The prefrontal cortex was processed for paraffin embedding, and sections stained for histological, histochemical and immunochemical evaluations. P < 0.05 was regarded as significant for data using one-way analysis of variance. Oxidative damage was observed in animals from the treatment groups when compared to the control. The analysed levels of oxidative stress markers showed statistically significant differences, except between groups given pooled sampled water and combined metals. Neurodegeneration was attested from the histological and histochemical evaluations, and the immunohistochemical evaluation revealed marked astrocytosis with induced oxidative stress while comparing the experimental groups
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Córtex Pré-Frontal
/
Metais Pesados
/
Doenças Neurodegenerativas
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Cérebro
/
Degeneração Neural
Limite:
Animais
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Kwara State University/Nigeria
/
Osun State University/Nigeria
/
University of Medical Sciences/Nigeria
/
University of Nigeria/Nigeria